| Autor: |
Chen M; Department of Epidemiology, University of Florida, Gainesville, United States of America., Huang Z; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, United States of America., Miao G; Department of Epidemiology, The University of Florida, Gainesville, United States of America., Ren J; Department of Epidemiology, University of Florida, Gainesville, United States of America., Liu J; Department of Epidemiology, University of Florida, Gainesville, United States of America., Roman MJ; Division of Cardiology, Weill Cornell Medical College, New York, United States of America., Devereux RB; Division of Cardiology, Weill Cornell Medical College, New York, United States of America., Fabsitz RR; Missouri Breaks Industries Research Inc, Eagle Butte, United States of America., Zhang Y; Department of Biostatistics and Epidemiology, The University of Oklahoma Health Sciences Center, Oklahoma City, United States of America., Umans JG; Center for Clinical and Translational Science, Georgetown-Howard Universities, Washington, United States of America., Cole SA; Department of Genetics, Texas Biomedical Research Institute, San Antonio, United States of America., Kelly TN; Department of Medicine, University of Illinois, Chicago, United States of America., Fiehn O; West Coast Metabolomics Center, University of California Davis, Davis, United States of America., Zhao J; Department of Epidemiology, University of Florida, Gainesville, United States of America. |
| Abstrakt: |
Left ventricular hypertrophy (LVH) and dyslipidemia are strong, independent predictors for cardiovascular disease, but their relationship is less well-studied. A longitudinal lipidomic profiling of left ventricular mass (LVM) and LVH is still lacking. Using LC-MS, we repeatedly measured 1,542 lipids from 1,755 unique American Indians attending two exams (mean~5-year apart). Cross-sectional associations of individual lipid species with LVM index (LVMI) were examined by generalized estimating equation (GEE), followed by replication in an independent bi-racial cohort (65% white, 35% black). Baseline plasma lipids associated with LVH risk beyond traditional risk factors were identified by Cox frailty model in American Indians. Longitudinal associations between changes in lipids and changes in LVMI were examined by GEE, adjusting for baseline lipids, baseline LVMI, and covariates. Multiple lipid species (e.g., glycerophospholipids, sphingomyelins, acylcarnitines) were significantly associated with LVMI or the risk of LVH in American Indians. Some lipids were confirmed in black and white individuals. Moreover, some LVH-related lipids were inversely associated with risk of coronary heart disease (CHD). Longitudinal changes in several lipid species (e.g., glycerophospholipids, sphingomyelins, cholesterol esters) were significantly associated with changes in LVMI. These findings provide insights into the role of lipid metabolism in LV remodeling and the risk of LVH or CHD. |
