Body fatness across the adult life course and ovarian cancer risk.

Autor: Ritonja JA; Department of Oncology, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada.; St. Mary's Research Centre, Montreal, QC, Canada., Madathil S; Faculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, QC, Canada., Nicolau B; Department of Oncology, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada.; Faculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, QC, Canada.; Department of Epidemiology, Biostatistics and Occupational Health, Faculty of Medicine, McGill University, Montreal, QC, Canada., L'Espérance K; Université de Montréal Hospital Research Centre (CRCHUM), Montréal, QC, Canada.; Department of Social and Preventive Medicine, Université de Montréal, Montréal, QC, Canada., Ho V; Université de Montréal Hospital Research Centre (CRCHUM), Montréal, QC, Canada.; Department of Social and Preventive Medicine, Université de Montréal, Montréal, QC, Canada., Abrahamowicz M; Department of Epidemiology, Biostatistics and Occupational Health, Faculty of Medicine, McGill University, Montreal, QC, Canada., Koushik A; Department of Oncology, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada. anita.koushik@mcgill.ca.; St. Mary's Research Centre, Montreal, QC, Canada. anita.koushik@mcgill.ca.; Université de Montréal Hospital Research Centre (CRCHUM), Montréal, QC, Canada. anita.koushik@mcgill.ca.
Jazyk: angličtina
Zdroj: European journal of epidemiology [Eur J Epidemiol] 2024 Oct 15. Date of Electronic Publication: 2024 Oct 15.
DOI: 10.1007/s10654-024-01161-1
Abstrakt: Excess body fatness in late adulthood has been observed to increase ovarian cancer risk, but the association is relatively weak. Body fatness can change over time, and timing may differently influence risk. We used a life course epidemiology approach to identify whether the relation between body fatness and ovarian cancer risk is best described by a critical period, accumulation or sensitive period hypothesis. In a population-based case-control study of ovarian cancer in Montreal, Canada (2011-16), data on body mass index (BMI) at each decade starting at age 20 was available. Among 363 cases and 707 controls aged ≥ 50 years, we used a Bayesian relevant life course exposure model to estimate the relative importance of BMI for three pre-specified periods across the adult life course, i.e., early childbearing years, late childbearing years, and peri/postmenopause, on ovarian cancer risk. The accumulation hypothesis best described BMI in relation to ovarian cancer overall, with an odds ratio (OR) for the lifetime effect of BMI (per 5 kg/m 2 increase) of 1.10 (95% credible interval [CrI]: 0.90-1.35). For invasive ovarian cancer, the OR (95% CrI) for the lifetime effect was 1.16 (0.92-1.48), with BMI during early childbearing years showing the highest relative importance, suggesting this may be a sensitive period. For borderline cancer, the lifetime effect OR was not strongly supportive of an association (OR: 0.90, 95% CrI: 0.53-1.32). The results suggest that a sensitive period of early childbearing years is a candidate hypothesis for further investigation.
(© 2024. Springer Nature B.V.)
Databáze: MEDLINE
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