First reported advanced pancreatic cancer with hyperprogression treated with PD-1 blockade combined with chemotherapy: a case report and literature review.

Autor: Wang YZ; Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai, 200032, China.; Cancer Center, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China., Peng MZ; Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai, 200032, China.; Cancer Center, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China., Xu YL; Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai, 200032, China.; Cancer Center, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China., Ying Y; Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai, 200032, China.; Cancer Center, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China., Tang LH; Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai, 200032, China.; Cancer Center, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China., Xu HX; Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai, 200032, China.; Cancer Center, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China., He JY; Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai, 200032, China.; Cancer Center, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China., Liu L; Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai, 200032, China. liuliang.zlhospital@fudan.edu.cn.; Cancer Center, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. liuliang.zlhospital@fudan.edu.cn.; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. liuliang.zlhospital@fudan.edu.cn., Wang WQ; Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai, 200032, China. wang.wenquan@zs-hospital.sh.cn.; Cancer Center, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. wang.wenquan@zs-hospital.sh.cn.; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. wang.wenquan@zs-hospital.sh.cn.
Jazyk: angličtina
Zdroj: Discover oncology [Discov Oncol] 2024 Oct 15; Vol. 15 (1), pp. 560. Date of Electronic Publication: 2024 Oct 15.
DOI: 10.1007/s12672-024-01420-3
Abstrakt: Pancreatic cancer is among the most immune-resistant tumor types due to its unique tumor microenvironment and low cancer immunogenicity. Single-agent immune modulators have thus far proven clinically ineffective. However, a growing body of evidence suggests that combination of these modulators with other strategies could unlock the potential of immunotherapy in pancreatic cancer. Herein, we describe the case of a 59-year-old male with metastatic pancreatic ductal adenocarcinoma, referred to our center to receive immunotherapy (serplulimab, a novel anti-PD-1 antibody) combined with chemotherapy (gemcitabine/nab-paclitaxel). During the initial three treatment cycles, the patient was assessed as having stable disease (SD) according to RECIST 1.1 criteria. However, following two additional cycles of combination therapy, the primary tumor mass increased from 4.9 cm to 13.2 cm, accompanied by the development of new lung lesions, ascites, and pelvic metastases. He succumbed to respiratory failure one month later. Retrospective analysis revealed that the patient had MDM4 amplification, identified as a high-risk factor for hyperprogressive disease (HPD). To our knowledge, this is the first reported case of HPD in pancreatic cancer with multiple metastases treated using combination therapy. We investigated the potential mechanisms and reviewed the latest literature on predictive factors for HPD. These findings suggest that while chemotherapy combined with immunotherapy may hold promise for treating pancreatic cancer, it is imperative to identify and closely monitor patients with high-risk factors for HPD when using immunotherapy.
(© 2024. The Author(s).)
Databáze: MEDLINE
Externí odkaz: