| Autor: |
Li S; Department of Chemistry, College of Basic Medicine, Army Medical University (Third Military Medical University), Chongqing, China.; Department of Gastroenterology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China.; Army 953 Hospital, Shigatse Branch of Xinqiao Hospital, Army Medical University (Third Military Medical University), Shigatse, Tibet Autonomous Region, China., Wu T; Department of Gastroenterology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China., Wu J; Department of Gastroenterology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China., Chen W; Department of Gastroenterology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China., Zhang D; Department of Chemistry, College of Basic Medicine, Army Medical University (Third Military Medical University), Chongqing, China. |
| Abstrakt: |
The gastrointestinal tract (GIT) is an important and complex system by which humans to digest food and absorb nutrients. The GIT is vulnerable to diseases, which may led to discomfort or even death in humans. Therapeutics for GIT disease treatment face multiple biological barriers, which significantly decrease the efficacy of therapeutics. Recognizing the biological barriers and pathophysiological characteristics of GIT may be helpful to design innovative therapeutics. Nanotherapeutics, which have special targeting and controlled therapeutic release profiles, have been widely used for the treatment of GIT diseases. Herein, we provide a comprehensive review of the biological barrier and pathophysiological characteristics of GIT, which may aid in the design of promising nanotherapeutics for GIT disease treatment. Furthermore, several typical diseases of the upper and lower digestive tracts, such as Helicobacter pylori infection and inflammatory bowel disease, were selected to investigate the application of nanotherapeutics for GIT disease treatment. |
