Shearmetry of Fluids with Tunable Rheology by Polarized Luminescence of Rare Earth-Doped Nanorods.

Autor:	Wang Z; Laboratoire de Physique de la Matière Condensée, Ecole Polytechnique, CNRS, IP Paris, 91128 Palaiseau, France.; L'Institut Mondor de Recherche Biomédicale, Université Paris Est Créteil, INSERM U955, CNRS, 94010 Créteil, France., Zou Q; Laboratoire de Physique de la Matière Condensée, Ecole Polytechnique, CNRS, IP Paris, 91128 Palaiseau, France., Magermans L; Laboratoire de Physique de la Matière Condensée, Ecole Polytechnique, CNRS, IP Paris, 91128 Palaiseau, France., Amselem G; Laboratoire d'Hydrodynamique, Ecole Polytechnique, CNRS, IP Paris, 91128 Palaiseau, France., Dessalles CA; Laboratoire d'Hydrodynamique, Ecole Polytechnique, CNRS, IP Paris, 91128 Palaiseau, France., Louis B; L'Institut Mondor de Recherche Biomédicale, Université Paris Est Créteil, INSERM U955, CNRS, 94010 Créteil, France., Filoche M; L'Institut Mondor de Recherche Biomédicale, Université Paris Est Créteil, INSERM U955, CNRS, 94010 Créteil, France.; Institut Langevin, ESPCI Paris, PSL University, CNRS, 75005 Paris, France., Gacoin T; Laboratoire de Physique de la Matière Condensée, Ecole Polytechnique, CNRS, IP Paris, 91128 Palaiseau, France., Kim J; Laboratoire de Physique de la Matière Condensée, Ecole Polytechnique, CNRS, IP Paris, 91128 Palaiseau, France.
Jazyk:	angličtina
Zdroj:	ACS nano [ACS Nano] 2024 Nov 05; Vol. 18 (44), pp. 30650-30657. Date of Electronic Publication: 2024 Oct 15.
DOI:	10.1021/acsnano.4c09493
Abstrakt:	Shear stress plays a critical role in regulating physiological processes within microcirculatory systems. While particle imaging velocimetry is a standard technique for quantifying shear flow, uncertainty near boundaries and low resolution remain severe restrictions. Additionally, shear stress determination is particularly challenging in biofluids due to their significant non-Newtonian behaviors. The present study develops a shearmetry technique in physiological settings using a biomimetic fluid containing rare earth-doped luminescent nanorods acting in two roles. First, they are used as colloidal additives adjusting rheological properties in physiological media. Their anisotropic morphology and interparticle interaction synergistically induce a non-Newtonian shear-thinning effect emulating real biofluids. Second, they can probe shear stress due to the shear-induced alignment. The polarized luminescence of the nanorods allows for quantifying their orientational order parameter and thus correlated shear stress. Using scanning confocal microscopy, we demonstrate the tomographic mapping of the shear stress distribution in microfluidics. High shear stress is evident near the constriction and the cellular periphery, in which non-Newtonian effects can have a significant impact. This emerging shearmetry technique is promising for implementation in physiological and rheological environments of biofluids.
Databáze:	MEDLINE
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