Changes in serum uteroglobin level in type 2 diabetes mellitus patients.

Autor:	Lim JY; Department of Endocrinology and Metabolism, Chungnam National University Hospital, Daejeon, Republic of Korea., Ju SH; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea., Kim JM; Department of Endocrinology and Metabolism, Chungnam National University Sejong Hospital, Sejong, Republic of Korea.; Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Republic of Korea., Yi HS; Department of Endocrinology and Metabolism, Chungnam National University Hospital, Daejeon, Republic of Korea.; Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Republic of Korea., Lee JH; Department of Endocrinology and Metabolism, Chungnam National University Hospital, Daejeon, Republic of Korea.; Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Republic of Korea., Kim HJ; Department of Endocrinology and Metabolism, Chungnam National University Hospital, Daejeon, Republic of Korea.; Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Republic of Korea., Ku BJ; Department of Endocrinology and Metabolism, Chungnam National University Hospital, Daejeon, Republic of Korea.; Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Republic of Korea., Joung KH; Department of Endocrinology and Metabolism, Chungnam National University Sejong Hospital, Sejong, Republic of Korea.; Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Republic of Korea.
Jazyk:	angličtina
Zdroj:	Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2024 Sep 30; Vol. 15, pp. 1416326. Date of Electronic Publication: 2024 Sep 30 (Print Publication: 2024).
DOI:	10.3389/fendo.2024.1416326
Abstrakt:	Background: Uteroglobin is a multifunctional protein with anti-inflammatory properties. Studies have revealed the importance of inflammation in type 2 diabetes mellitus (T2D) pathogenesis. Here, we investigated the relationship between uteroglobin and T2D. Methods: We performed diagnostic tests for diabetes in subjects who had not been diagnosed with or treated for T2D. We established three groups, containing those with normal glucose tolerance (NGT), prediabetes and T2D, consisting of 80 people each, and compared their uteroglobin levels. In addition, 28 patients newly diagnosed with T2D were treated with metformin for 12 weeks, and 63 patients newly diagnosed with dyslipidaemia during the treatment for T2D were treated with statin for 12 weeks. Results: This study showed that uteroglobin levels were significantly lower in prediabetes and T2D groups than in the NGT group. Uteroglobin levels were not significantly correlated with other metabolic parameters, except BMI, HOMA-β and eGFR. In the group treated with metformin or statin, uteroglobin levels increased after treatment compared to before treatment. Conclusions: Uteroglobin is a sensitive factor that was decreased even in prediabetes and increased upon treatment with drugs with anti-inflammatory effects. Uteroglobin is a potential early biomarker that reflects a chronic inflammatory condition in T2D. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Lim, Ju, Kim, Yi, Lee, Kim, Ku and Joung.)
Databáze:	MEDLINE
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