Antibiotic susceptibility of Pseudomonas aeruginosa in Saudi Arabia: a national antimicrobial resistance surveillance study.

Autor:	Thabit AK; Department of Pharmacy Practice, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia., Alghamdi AM; Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia., Miaji MY; Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia., Alharbi FS; Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia., Jawah AF; Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia., Alturki F; Department of Microbiology, King Fahad Hospital of the University, Dammam, Saudi Arabia., Hosin N; Department of Microbiology, College of Medicine, Imam Abdulrahman Bin Faisal University, Al Khobar, Saudi Arabia., Bazuqamah M; Department of Microbiology, King Khaled Hospital, Najran, Saudi Arabia., Almutairi MS; Department of Pharmacy Practice, College of Pharmacy, Qassim University, Qassim, Saudi Arabia., Alhamed H; Department of Laboratory and Blood Bank, King Fahad Specialist Hospital, Qassim, Saudi Arabia., Elhendawy A; Department of Microbiology, King Fahad Hospital, Al-Baha, Saudi Arabia., Atallah D; Department of Clinical Microbiology, King Abdulaziz University Hospital, Jeddah, Saudi Arabia., Humadi AA; Department of Laboratory and Blood Bank, King Fahad Specialist Hospital, Tabuk, Saudi Arabia., Alfifi KA; Department of Microbiology, King Fahad Specialist Hospital, Tabuk, Saudi Arabia., Alfadel K; Department of Microbiology, Maternity and Children Hospital, King Salman Medical City, Madinah, Saudi Arabia., Eljaaly K; Department of Pharmacy Practice, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia., Elfaky MA; Department of Natural Products, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.; Centre for Artificial Intelligence in Precision Medicines, King Abdulaziz University, Jeddah, Saudi Arabia.
Jazyk:	angličtina
Zdroj:	Frontiers in public health [Front Public Health] 2024 Sep 30; Vol. 12, pp. 1436648. Date of Electronic Publication: 2024 Sep 30 (Print Publication: 2024).
DOI:	10.3389/fpubh.2024.1436648
Abstrakt:	Background: Pseudomonas aeruginosa is a common pathogen causing healthcare-associated infections. Most surveillance studies from Saudi Arabia that assessed the resistance by P. aeruginosa were conducted in single centers or did not use broth microdilution (BMD), the gold standard test. This is the first national multicenter study to assess the resistance profiles of P. aeruginosa isolates in Saudi Arabia using BMD. Methods: Between 2022 and 2023, isolates from various infection sites were collected from seven hospitals in seven different regions of Saudi Arabia. The isolates were shipped to an academic microbiology lab, where their susceptibility was tested by BMD following Clinical Laboratory Standards Institute guidelines using Sensititre GNX3F plates. %Susceptibility to each antibiotic, and MIC50 and MIC90 were determined. Results: In total, 185 P. aeruginosa isolates were collected. Most isolates came from respiratory specimens (34.1%), followed by urine (21.1%) and skin/soft tissue (17.8%). The highest susceptibility was to amikacin (76.8%). Concurrently, susceptibility to meropenem was 52%, but it was 43.8% to colistin. While all P. aeruginosa isolates met the definition of multidrug-resistance, 41 (22.2%) were difficult-to-treat and 10 (5.4%) were pandrug-resistant. Difficult-to-treat isolates made up 30.3% of skin and soft tissue isolates, 25.4% of respiratory isolates, 21.7% of blood isolates, and 17.9% of urine isolates. Conclusion: Pseudomonas aeruginosa demonstrated an unexpectedly high level of resistance to several commonly used antibiotics. Therefore, antimicrobial stewardship and infection control policies should be strictly enforced by hospitals across the country to optimize treatment, prevent the emergence and spread of resistant strains, and track resistance trends with local antibiograms. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. (Copyright © 2024 Thabit, Alghamdi, Miaji, Alharbi, Jawah, Alturki, Hosin, Bazuqamah, Almutairi, Alhamed, Elhendawy, Atallah, Humadi, Alfifi, Alfadel, Eljaaly, Elfaky and the Saudi AntiMicrobial Surveillance (SAMS) study group.)
Databáze:	MEDLINE
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