Machine learning-driven survival prediction in gestational trophoblastic neoplasms: a focus on PSTT and ETT prognosis.

Autor:	Alshwayyat S; Faculty of Medicine, Jordan University of Science & Technology, Irbid, Jordan., Haddadin Z; Faculty of Medicine, Jordan University of Science & Technology, Irbid, Jordan., Alshwayyat M; Faculty of Medicine, Jordan University of Science & Technology, Irbid, Jordan., Alshwayyat TA; Faculty of Medicine, Jordan University of Science & Technology, Irbid, Jordan., Odat RM; Faculty of Medicine, Jordan University of Science & Technology, Irbid, Jordan., Al-Kurdi MA; Faculty of Medicine, University of Aleppo, Aleppo, Syria., Kharmoum S; Médical Oncology, Régional Hospital Center, Tangier, Morocco.
Jazyk:	angličtina
Zdroj:	Frontiers in oncology [Front Oncol] 2024 Sep 30; Vol. 14, pp. 1457531. Date of Electronic Publication: 2024 Sep 30 (Print Publication: 2024).
DOI:	10.3389/fonc.2024.1457531
Abstrakt:	Introduction: The clinicopathological characteristics and prognosis of placental site trophoblastic tumor (PSTT) and epithelioid trophoblastic tumor (ETT) have not been well summarized. Consequently, we conducted the largest to date series of samples of both types and employed machine learning (ML) to assess treatment effectiveness and develop accurate prognostic models for patients with GTN. Gestational choriocarcinoma (GCC) was used as the control group to show the clinical features of PTSS and ETT. Methods: The Surveillance, Epidemiology, and End Results (SEER) database provided the data used for this study's analysis. To identify the prognostic variables, we conducted Cox regression analysis and constructed prognostic models using five ML algorithms to predict the 5-year survival. A validation method incorporating the area under the curve (AUC) of the receiver operating characteristic (ROC) curve was used to validate the accuracy and reliability of the ML models. We also investigated the role of multiple therapeutic options using the Kaplan-Meier survival analysis. Results: The study population comprised 725 patients. Among them, 139 patients had ETT, 107 had PSTT, and 479 had GCC. There were no significant differences in survival between the different tumor groups. Multivariate Cox regression analysis revealed that metastasis was a significant prognostic factor for GCC, while older age and radiotherapy were significant prognostic factors for PTSS and ETT. ML models revealed that the Gradient Boosting classifier accurately predicted the outcomes, followed by the random forest classifier, K-Nearest Neighbors, Logistic Regression, and multilayer perceptron models. The most significant contributing factors were tumor size, year of diagnosis, age, and race. Discussion: Our study provides a method for treatment and prognostic assessment of patients with GTN. The ML we developed can be used as a convenient individualized tool to facilitate clinical decision making. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Alshwayyat, Haddadin, Alshwayyat, Alshwayyat, Odat, Al-kurdi and Kharmoum.)
Databáze:	MEDLINE
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