Small extracellular vesicles contain metals and transfer metal intercellularly.

Autor: Purnianto A; The Florey Institute of Neuroscience and Mental Health The University of Melbourne Parkville Victoria Australia., Mawal C; The Florey Institute of Neuroscience and Mental Health The University of Melbourne Parkville Victoria Australia., Kulkarni MM; The Florey Institute of Neuroscience and Mental Health The University of Melbourne Parkville Victoria Australia., Su H; The Florey Institute of Neuroscience and Mental Health The University of Melbourne Parkville Victoria Australia., Koukoulis TF; The Florey Institute of Neuroscience and Mental Health The University of Melbourne Parkville Victoria Australia., Wongsodirdjo P; The Florey Institute of Neuroscience and Mental Health The University of Melbourne Parkville Victoria Australia., Hung YH; The Florey Institute of Neuroscience and Mental Health The University of Melbourne Parkville Victoria Australia., Ayton S; The Florey Institute of Neuroscience and Mental Health The University of Melbourne Parkville Victoria Australia., Bush AI; The Florey Institute of Neuroscience and Mental Health The University of Melbourne Parkville Victoria Australia., Barnham KJ; The Florey Institute of Neuroscience and Mental Health The University of Melbourne Parkville Victoria Australia., Vella LJ; The Florey Institute of Neuroscience and Mental Health The University of Melbourne Parkville Victoria Australia.; Department of Surgery, The Royal Melbourne Hospital, Australia The University of Melbourne Parkville Victoria Australia.
Jazyk: angličtina
Zdroj: Journal of extracellular biology [J Extracell Biol] 2024 Oct 14; Vol. 3 (10), pp. e70012. Date of Electronic Publication: 2024 Oct 14 (Print Publication: 2024).
DOI: 10.1002/jex2.70012
Abstrakt: Cells have developed a highly regulated system for the uptake, transport, utilization, storage, and export of metals, ensuring the maintenance of cellular homeostasis. Small extracellular vesicles (sEVs) function as a mechanism through which a cell can export its cargo and transfer it to recipient cells. However, in contrast to the other molecular cargo associated with sEVs, the metal content of sEVs is not well characterized. To address this gap in knowledge, we measured the levels of nine essential metals (copper, iron, zinc, manganese, magnesium, potassium, calcium, chromium, cobalt) and six non-essential metals (nickel, rubidium, titanium, aluminium, lithium, lead) in sEVs originating from multiple in vitro and ex vivo sources. Our findings reveal that, beyond containing redox-active essential metals and those involved in redox reactions, sEVs also exhibit the capability to export and transfer non-physiological, potentially toxic metals.
Competing Interests: The authors report no conflict of interest.
(© 2024 The Author(s). Journal of Extracellular Biology published by Wiley Periodicals LLC on behalf of International Society for Extracellular Vesicles.)
Databáze: MEDLINE
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