Aflatoxins and fumonisins co-contamination effects on laying hens and use of mycotoxin detoxifiers as a mitigation strategy.

Autor: Ochieng PE; Department of Food Sciences, Laboratory of Food Analysis, Faculty of Veterinary Medicine, University of Liège, 4000, Liège, Belgium.; Department of Pathobiology, Pharmacology and Zoological Medicine, Laboratory of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ghent University, 9820, Merelbeke, Belgium., Kemboi DC; Department of Pathobiology, Pharmacology and Zoological Medicine, Laboratory of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ghent University, 9820, Merelbeke, Belgium.; Department of Animal Science, Chuka University, P.O. Box 109-60400, 00625, Chuka, Kenya., Okoth S; Department of Biology, Faculty of Science and Technology, University of Nairobi, P.O. Box 30197-00100, Nairobi, Kenya., De Baere S; Department of Pathobiology, Pharmacology and Zoological Medicine, Laboratory of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ghent University, 9820, Merelbeke, Belgium., Cavalier E; Department of Clinical Chemistry, Center for Interdisciplinary Research On Medicines (CIRM), University of Liège, University Hospital of Liège, 4000, Liège, Belgium., Kang'ethe E; Consultant, 00100, Nairobi, Kenya., Doupovec B; dsm-firmenich Animal Nutrition and Health R&D Center Tulln, 3430, Tulln, Austria., Gathumbi J; Department of Veterinary Pathology, Microbiology, and Parasitology, Faculty of Veterinary Medicine, University of Nairobi, P.O. Box 29053-00100, Nairobi, Kenya., Scippo ML; Department of Food Sciences, Laboratory of Food Analysis, Faculty of Veterinary Medicine, University of Liège, 4000, Liège, Belgium., Antonissen G; Department of Pathobiology, Pharmacology and Zoological Medicine, Laboratory of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ghent University, 9820, Merelbeke, Belgium.; Chair Poultry Health Sciences, Faculty of Veterinary Medicine, Ghent University, 9820, Merelbeke, Belgium., Lindahl JF; International Livestock Research Institute (ILRI), P.O. Box 30709-00100, Nairobi, Kenya. johanna.lindahl@imbim.uu.se.; Department of Medical Biochemistry and Microbiology, Uppsala University, 751 05, Uppsala, Sweden. johanna.lindahl@imbim.uu.se.; Department of Clinical Sciences, Swedish University of Agricultural Sciences, 750 07, Uppsala, Sweden. johanna.lindahl@imbim.uu.se., Croubels S; Department of Pathobiology, Pharmacology and Zoological Medicine, Laboratory of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ghent University, 9820, Merelbeke, Belgium. Siska.Croubels@ugent.be.
Jazyk: angličtina
Zdroj: Mycotoxin research [Mycotoxin Res] 2024 Oct 15. Date of Electronic Publication: 2024 Oct 15.
DOI: 10.1007/s12550-024-00566-x
Abstrakt: This study examined the effects of fumonisins (FBs) and aflatoxin B1 (AFB1), alone or in combination, on the productivity and health of laying hens, as well as the transfer of aflatoxins (AFs) to chicken food products. The efficacy and safety of mycotoxin detoxifiers (bentonite and fumonisin esterase) to mitigate these effects were also assessed. Laying hens (400) were divided into 20 groups and fed a control, moderate (54.6 µg/kg feed) or high (546 µg/kg feed) AFB1 or FBs (7.9 mg/kg feed) added diets, either alone or in combination, with the mycotoxin detoxifiers added in selected diets. Productivity was evaluated by feed intake, egg weight, egg production, and feed conversion ratio whereas health was assessed by organ weights, blood biochemistry, and mortality. Aflatoxins residues in plasma, liver, muscle, and eggs were determined using UHPLC-MS/MS methods. A diet with AFB1 at a concentration of 546 µg/kg feed decreased egg production and various AFB1-contaminated diets increased serum uric acid levels and weights of liver, spleen, heart, and gizzard. Interactions between AFB1 and FBs significantly impacted spleen, heart, and gizzard weights as well as AFB1 residues in eggs. Maximum AFB1 residues of 0.64 µg/kg and aflatoxin M1 (below limits of quantification) were observed in liver, plasma, and eggs of layers fed diets with AFB1. The mycotoxin detoxifiers reduced effects of AFB1 and FBs on egg production, organ weights, blood biochemistry, and AFB1 residues in tissues. This study highlights the importance of mycotoxin detoxifiers as a mitigation strategy against mycotoxins in poultry production.
(© 2024. The Author(s).)
Databáze: MEDLINE
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