Risk factors for endogenous endophthalmitis in infectious endocarditis patients.

Autor: Shah MK; Institute of Ophthalmology & Visual Science, Rutgers New Jersey Medical School, Newark, NJ, 07103, USA., Zhu A; Institute of Ophthalmology & Visual Science, Rutgers New Jersey Medical School, Newark, NJ, 07103, USA., Uppuluri A; Institute of Ophthalmology & Visual Science, Rutgers New Jersey Medical School, Newark, NJ, 07103, USA., Henry RK; Institute of Ophthalmology & Visual Science, Rutgers New Jersey Medical School, Newark, NJ, 07103, USA., Zarbin MA; Institute of Ophthalmology & Visual Science, Rutgers New Jersey Medical School, Newark, NJ, 07103, USA., Bhagat N; Institute of Ophthalmology & Visual Science, Rutgers New Jersey Medical School, Newark, NJ, 07103, USA. bhagatne@njms.rutgers.edu.
Jazyk: angličtina
Zdroj: Eye (London, England) [Eye (Lond)] 2024 Oct 14. Date of Electronic Publication: 2024 Oct 14.
DOI: 10.1038/s41433-024-03390-w
Abstrakt: Background/objectives: The purpose of this study was to identify demographic variables and systemic comorbidities that may increase risk of endogenous endophthalmitis (EE) development in patients with infective endocarditis (IE).
Subjects/methods: A retrospective database study was conducted using the 2002-2014 National Inpatient Sample (NIS). Patients with IE and EE were identified using ICD-9-CM codes. Descriptive chi-square and logistic regression analysis identified risk factors for EE in IE patients.
Results: Of 769,472 inpatients with a diagnosis of IE, 2248 had a diagnosis of EE. Women comprised 39.7% of IE patients without EE and 42.6% of those with EE (p = 0.005). The majority of IE cases with EE were in those 21-64-year-old (58.5%) age cohort and 67.4% of cases were Whites. Multivariate analysis revealed IE patients in the 21-64 (OR, 3.660) and 65+ age group (OR, 2.852) had increased risk of developing EE compared to the 0-20-year-old group. Hispanic (OR, 1.377) and Asian/Pacific Islander (OR, 1.620) patients had increased risk compared to White patients. Diabetes with (OR, 2.043) and without (OR, 1.433) chronic complications, alcohol use disorder (AUD; OR, 1.795), and cirrhosis (OR, 1.452) conferred an increased risk of developing EE, whereas, congestive heart failure (CHF; OR, 0.716), arrhythmia (OR, 0.678), and having a cardiac device (OR, 0.336) decreased risk of EE in IE subjects.
Conclusion: Older age (21+ years) and Hispanic and Asian/Pacific Islander background were associated with increased risk of developing EE in IE patients. Diabetes with and without chronic complications, AUD, or cirrhosis also conferred a 1.5-2 times increased risk. CHF, arrhythmia, or having a cardiac device were associated with decreased risk.
(© 2024. The Author(s).)
Databáze: MEDLINE
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