Intensity dependence of auditory evoked potentials distinguish participants with unmedicated depression from non-depressed controls.

Autor: Kangas ES; Department of Psychology, University of Jyvaskyla, Jyväskylä, Finland., Li X; Department of Psychology, University of Jyvaskyla, Jyväskylä, Finland., Vuoriainen E; Human Information Processing Laboratory, Faculty of Social Sciences/Psychology, Tampere University, Tampere, Finland., Lindeman S; Wellbeing Services County of Central Finland, Jyväskylä, Finland.; Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland., Astikainen P; Department of Psychology, University of Jyvaskyla, Jyväskylä, Finland.
Jazyk: angličtina
Zdroj: The European journal of neuroscience [Eur J Neurosci] 2024 Nov; Vol. 60 (10), pp. 6440-6469. Date of Electronic Publication: 2024 Oct 14.
DOI: 10.1111/ejn.16569
Abstrakt: Depression is a heterogeneous syndrome that impacts an individual's emotional, social, cognitive and bodily functioning. Depression is associated with biases in emotional processing, but alterations in basic sensory processing have received less attention in depression research. Here, we measured event-related potentials (ERPs) in response to changes in the intensity of auditory stimuli and the location of somatosensory stimuli in participants with depression and in non-depressed control participants. We tested whether auditory mismatch negativity, P3a or N1 intensity dependence response or somatosensory mismatch response, P3a, P50 or N80 can dissociate depressed participants and non-depressed controls, and we also analysed the effects of depression medication and age in this sample. N1 intensity dependence response was increased in unmedicated depressed participants relative to non-depressed controls. When age was controlled for in the analysis, the effect of depression was only at a trend level. N1 intensity dependence response correlated with depression severity at the whole sample level. We did not observe any depression-related alterations in auditory mismatch negativity or P3a or somatosensory ERPs. Our results may reflect an association between the N1 intensity dependence response and altered neurotransmitter activity in depression, but this should be confirmed in future studies.
(© 2024 The Author(s). European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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