Effect of Photobiomodulation on an Experimental Model of Lower Limb Ischemia.

Autor: Perez ST; Postgraduate Program in Biophotonics Medicine, Nove de Julho University/UNINOVE, São Paulo, Brazil.; Conjunto Hospitalar Do Mandaqui, São Paulo, Brazil., Andreo L; Postgraduate Program in Biophotonics Medicine, Nove de Julho University/UNINOVE, São Paulo, Brazil., Junior JAS; Postgraduate Program in Biophotonics Medicine, Nove de Julho University/UNINOVE, São Paulo, Brazil.; Postgraduate Program in Medicine, Nove de Julho University/UNINOVE, São Paulo, Brazil., Bussadori SK; Postgraduate Program in Biophotonics Medicine, Nove de Julho University/UNINOVE, São Paulo, Brazil.; Postgraduate Program in Rehabilitation Sciences, Nove de Julho University/UNINOVE, São Paulo, Brazil., Horliana ACRT; Postgraduate Program in Biophotonics Medicine, Nove de Julho University/UNINOVE, São Paulo, Brazil., Mesquita-Ferrari RA; Postgraduate Program in Biophotonics Medicine, Nove de Julho University/UNINOVE, São Paulo, Brazil.; Postgraduate Program in Rehabilitation Sciences, Nove de Julho University/UNINOVE, São Paulo, Brazil., Fernandes KPS; Postgraduate Program in Biophotonics Medicine, Nove de Julho University/UNINOVE, São Paulo, Brazil.
Jazyk: angličtina
Zdroj: Journal of biophotonics [J Biophotonics] 2024 Oct 14, pp. e202400305. Date of Electronic Publication: 2024 Oct 14.
DOI: 10.1002/jbio.202400305
Abstrakt: Photobiomodulation (PBM) has been shown to be promising for the promotion of angiogenesis. The present study investigated the effects of PBM on vascularization in an animal model of peripheral artery disease. Wistar rats were divided into three groups. The control group received no procedures. The ischemia group was submitted to ligation of the femoral artery of the hindleg. The ischemia + PBM group was submitted to ligation of the femoral artery followed by PBM (660 and 808 nm, 100 mW, 4 J) over the site. Animals with ischemia treated with PBM exhibited comparable results to the control group with regards to the diameter of the α-SMA+ vessels, cross-sectional area of muscle fibers, percentage of collagen and serum concentration of IL-17A, as well as similarities in terms of vertical mobility, temperature of the hindleg, number of acts of grooming, and percentage of movement, indicating a condition like that of limbs unaffected by ischemia.
(© 2024 Wiley‐VCH GmbH.)
Databáze: MEDLINE
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