Synergetic effects of tetracycline hydrochloride incorporated regenerated cellulose acetate - Bacterial cellulose hybrid nanocomposite: Potential in biomedical application.

Autor: Khan MR; Key Laboratory of Eco-Textiles, Ministry of Education, College of Textile and Clothing, Jiangnan University, Wuxi 214122, China., Liao S; Jiangxi Centre for Modern Apparel Engineering and Technology, Jiangxi Institute of Fashion Technology, Nanchang 330201, China., Wasim M; Key Laboratory of Eco-Textiles, Ministry of Education, College of Textile and Clothing, Jiangnan University, Wuxi 214122, China; College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China. Electronic address: muhammad_wasim786@szu.edu.cn., Farooq A; School of Textile and Garment, Anhui Polytechnic University, Wuhu, Anhui, China; School of Textile and Clothing, Qingdao University, Qingdao, China., Wang Q; Key Laboratory of Eco-Textiles, Ministry of Education, College of Textile and Clothing, Jiangnan University, Wuxi 214122, China. Electronic address: qqwang@jiangnan.edu.cn., Wei Q; Key Laboratory of Eco-Textiles, Ministry of Education, College of Textile and Clothing, Jiangnan University, Wuxi 214122, China; Jiangxi Centre for Modern Apparel Engineering and Technology, Jiangxi Institute of Fashion Technology, Nanchang 330201, China. Electronic address: qfwei@jiangnan.edu.cn.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2024 Oct 12; Vol. 281 (Pt 4), pp. 136563. Date of Electronic Publication: 2024 Oct 12.
DOI: 10.1016/j.ijbiomac.2024.136563
Abstrakt: Litter from cigarette waste is a significant threat to organisms and ecosystems. However, this waste contains cellulose acetate (CA) that can be recycled into raw materials. In this study, recycled CA from cigarettes (CFCA) electrospun through electro-spinning technique and developed hybrid nanocomposite by incorporating CFCA in the fermentation media, followed by self-assembly of bacterial cellulose (BC). CFCA exhibit excessive hydrophobicity due to their high crystallinity and reorientation of hydrophobic groups. We aimed to improve the hydrophilic, thermal and mechanical properties of CFCA. We examined fiber morphology using a scanning electron microscope (SEM), Fourier Transform Infrared Spectroscopy (FTIR), X-ray Diffraction Analysis (XRD), thermogravimetric analysis (TGA), swelling capacity and mechanical properties. BC/CFCA showed higher swelling capacity, improved thermal properties, and good tensile strength compared to CFCA. Additionally, tetracycline hydrochloride (TC) was loaded into developed BC/CFCA matrix and evaluated in-vitro drug release, antibacterial activity and cytotoxicity. In-vitro drug release results showed that developed BC/CFCA can able to control TC release. In addition, prepared BC/CFCA-TC composites demonstrated excellent antibacterial activity against gram-positive and gram-negative bacteria. More importantly, BC/CFCA-TC composites exhibit good cytotoxicity on mouse fibroblast cells (L929). These characteristics of BC/CFCA-TC membranes indicate they may successfully serve as wound dressings and other medical biomaterials.
Competing Interests: Declaration of competing interest The authors don't have any conflict of interest.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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