Effects of glucagon-like peptide-1 receptor agonists on endoscopy outcomes: A systematic review & meta-analysis.

Autor: Singh S; Internal Medicine, Sinai Hospital of Baltimore, Baltimore, MD, USA. Electronic address: sahib_aries2003@yahoo.co.in., Rahman SH; Internal Medicine, Methodist Dallas Medical Center, Dallas, TX, USA. Electronic address: hamaadrahman1@gmail.com., Khan N; Internal Medicine, AdventHealth Orlando, Orlando, FL. Electronic address: khanz.nihal@gmail.com., Rajagopal A; Internal Medicine, University of Connecticut, CT, USA. Electronic address: dranjalirajagopal@gmail.com., Shafique N; Internal Medicine, AdventHealth Orlando, Orlando, FL. Electronic address: noumanshafique007@hotmail.com., Tawde P; Medical Student, Avalon University School of Medicine, Curacao, Dutch Caribbean. Electronic address: poonam.tawde21@gmail.com., Bhardwaj V; Gastroenterology & Hepatology, Ram Manohar Lohia hospital (PGIMER RML), New Delhi, India. Electronic address: drvaishali22.DB@gmail.com., Suresh Kumar VC; Gastroenterology & Hepatology, State University of New York Upstate Medical University, Syracuse, New York, USA. Electronic address: drvishnucharan@gmail.com., Aswath G; Gastroenterology & Hepatology, State University of New York Upstate Medical University, Syracuse, New York, USA. Electronic address: aswathg@upstate.edu., Inamdar S; Gastroenterology & Hepatology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA. Electronic address: sumant.c.inamdar@gmail.com., Dutta S; Gastroenterology & Hepatology, Sinai Hospital of Baltimore, Baltimore, MD, USA. Electronic address: sudhirdutta10@gmail.com., Hurairah A; Internal Medicine, AdventHealth Orlando, Orlando, FL. Electronic address: abuhurairah.md@gmail.com., Mohan BP; Gastroenterology & Hepatology, Orlando Gastroenterology PA, Orlando, FL, USA. Electronic address: dr.babu.pm@gmail.com.
Jazyk: angličtina
Zdroj: Gastrointestinal endoscopy [Gastrointest Endosc] 2024 Oct 12. Date of Electronic Publication: 2024 Oct 12.
DOI: 10.1016/j.gie.2024.10.011
Abstrakt: Background and Aims: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are known to cause delayed gastric emptying, however the effect on clinical outcomes during upper endoscopy/colonoscopy remains unclear. We conducted a meta-analysis to reconcile the data.
Methods: Online databases were searched for studies evaluating GLP-1RAs vs control group (no GLP-1RAs) in patients undergoing endoscopy. The outcomes of interest were rate of retained gastric contents (RGC), aborted procedures, aspiration events and subjective bowel preparation quality. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using a random-effects model.
Results: A total of 23 studies with 77,271 patients (4,449 in the GLP-1 RA arm and 72,703 in the control arm) were included. The mean age ranged from 47.6 to 72 years and 58.4% were females. As compared to the control group, the GLP-1 RA group had higher odds of RGC (OR 15.39, 95% CI 4.65-50.99, p < 0.01) and aborted procedures (OR 13.86, 95% CI 4.42-43.43, p < 0.01). No significant differences were observed between the two groups in terms of aspiration events (OR 21.06, 95% CI 0.13-3379.01, p=0.24) and subjective bowel preparation quality (OR 0.94, 95% CI 0.67-1.31, p=0.83).
Conclusion: While statistical significance was reached in terms of visible RGC and early termination of endoscopies in patients on GLP-1RAs, these events were overall rare. GLP-1RAs do not appear to pose significant risk, as the odds of developing aspiration were comparable in the two groups.
(Copyright © 2024 American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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