The relationship between ON-OFF function and OCT structural and angiographic parameters in early diabetic retinal disease.

Autor: Tang VTS; Department of Optometry and Vision Sciences, The University of Melbourne, Parkville, Victoria, Australia.; Division of Optometry, School of Allied Health, University of Western Australia, Perth, Western Australia, Australia., Symons RCA; Department of Optometry and Vision Sciences, The University of Melbourne, Parkville, Victoria, Australia.; Department of Surgery, The University of Melbourne, Parkville, Victoria, Australia.; Centre for Eye Research Australia, East Melbourne, Victoria, Australia.; Department of Surgery, Alfred Hospital, Monash University, Clayton, Victoria, Australia., Fourlanos S; Department Diabetes and Endocrinology, Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia.; Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia.; Australian Centre for Accelerating Diabetes Innovations, The University of Melbourne, Parkville, Victoria, Australia., Guest D; Department of Optometry and Vision Sciences, The University of Melbourne, Parkville, Victoria, Australia., McKendrick AM; Department of Optometry and Vision Sciences, The University of Melbourne, Parkville, Victoria, Australia.; Division of Optometry, School of Allied Health, University of Western Australia, Perth, Western Australia, Australia.; Lions Eye Institute, Nedlands, Western Australia, Australia.
Jazyk: angličtina
Zdroj: Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) [Ophthalmic Physiol Opt] 2025 Jan; Vol. 45 (1), pp. 77-88. Date of Electronic Publication: 2024 Oct 14.
DOI: 10.1111/opo.13394
Abstrakt: Purpose: This study measured associations between ON and OFF functional indicators and structural optical coherence tomography (OCT) and OCT angiography (OCTA) markers in diabetic retinal disease.
Methods: Fifty-four participants with type 1 or type 2 diabetes (mean age = 34.1 years; range 18-60) and 48 age-matched controls (mean age = 35.4 years, range 18-59) underwent visual psychophysical testing, OCT and OCTA retinal imaging. Psychophysical tasks measuring (A) contrast increment and decrement sensitivity and (B) response times to increment and decrement targets were assessed as surrogate measures of ON and OFF retinal ganglion cell function.
Results: The group with diabetes had worse foveal contrast increment and decrement thresholds (p = 0.04) and were slower to search for increment and decrement targets relative to controls (p = 0.009). Individuals with diabetes had a less circular foveal avascular zone (FAZ) (p < 0.001) but did not differ from controls in foveal vessel density and FAZ area. Functional and structural outcome measures related to the peripheral retina were also comparable between those with and without diabetes. Functional responses to increments and decrements were not significantly correlated with FAZ circularity or vessel density in individuals with diabetes.
Conclusions: Diabetic retinal disease results in impaired performance on measures of inferred ON and OFF pathway function in addition to vascular deficits measurable with OCTA. Future longitudinal studies may determine the temporal relationship between these deficits, and whether they predict future diabetic retinopathy.
(© 2024 The Author(s). Ophthalmic and Physiological Optics published by John Wiley & Sons Ltd on behalf of College of Optometrists.)
Databáze: MEDLINE
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