Cancer-on-chip: a breakthrough organ-on-a-chip technology in cancer cell modeling.

Autor: Nejati B; Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Shahhosseini R; Faculty of Medicine, Istanbul Medipol University, Istanbul, Turkey., Hajiabbasi M; Islamic Azad University of Tonekabon, Tonekabon, Iran., Ardabili NS; Department of Midwifery, Ardabil Branch, Islamic Azad University, Ardabil, Iran., Baktash KB; Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran., Alivirdiloo V; Ramsar Campus, Mazandaran University of Medical Sciences, Ramsar, Iran., Moradi S; Department of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran., Rad MF; Faculty of Medicine, Yazd University of Medical Sciences, Yazd, Iran., Rahimi F; Division of Clinical Laboratory, Zahra Mardani Azar Children Training Research and Treatment Center, Tabriz University of Medical Sciences, Tabriz, Iran., Farani MR; Faculty of Allied Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Ghazi F; Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran., Mobed A; Department of Community Medicine, Faculty of Medicine, Social Determinants of Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Alipourfard I; Institute of Physical Chemistry, Polish Academy of Sciences, Marcina Kasprzaka 44/52, 01-224, Warsaw, Poland. ialipourfard@ichf.edu.pl.
Jazyk: angličtina
Zdroj: Medical & biological engineering & computing [Med Biol Eng Comput] 2024 Oct 14. Date of Electronic Publication: 2024 Oct 14.
DOI: 10.1007/s11517-024-03199-5
Abstrakt: Cancer remains one of the leading causes of death worldwide. The unclear molecular mechanisms and complex in vivo microenvironment of tumors make it difficult to clarify the nature of cancer and develop effective treatments. Therefore, the development of new methods to effectively treat cancer is urgently needed and of great importance. Organ-on-a-chip (OoC) systems could be the breakthrough technology sought by the pharmaceutical industry to address ever-increasing research and development costs. The past decade has seen significant advances in the spatial modeling of cancer therapeutics related to OoC technology, improving physiological exposition criteria. This article aims to summarize the latest achievements and research results of cancer cell treatment simulated in a 3D microenvironment using OoC technology. To this end, we will first discuss the OoC system in detail and then demonstrate the latest findings of the cancer cell treatment study by Ooc and how this technique can potentially optimize better modeling of the tumor. The prospects of OoC systems in the treatment of cancer cells and their advantages and limitations are also among the other points discussed in this study.
(© 2024. The Author(s).)
Databáze: MEDLINE
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