The role of kinesin superfamily proteins in hepatocellular carcinoma.

Autor: Ghnim ZS; College of Pharmacy, Al-Noor University, Mosul, Iraq., Mahdi MS; College of MLT, Ahl Al Bayt University, Karbala, Iraq., Ballal S; Department of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to Be University), Bangalore, Karnataka, India. suhasballal614@gmail.com., Chahar M; Department of Chemistry, NIMS Institute of Engineering & Technology, NIMS University, Jaipur, Rajasthan, India., Verma R; Department of Applied Sciences, Chandigarh Engineering College, Chandigarh Group of Colleges, Jhanjeri, Mohali, Amritsar, Punjab, 140307, India., Al-Nuaimi AMA; Gilgamesh Ahliya University, Baghdad, Iraq., Kumar MR; Department of Chemistry, Raghu Engineering College, Visakhapatnam, Andhra Pradesh, 531162, India., Al-Hussein RKA; Collage of Nursing, National University of Science and Technology, Dhi Qar, 64001, Iraq., Adil M; Pharmacy College, Al-Farahidi University, Baghdad, Iraq., Jawad MJ; Department of Pharmacy, Al-Zahrawi University College, Karbala, Iraq.
Jazyk: angličtina
Zdroj: Medical oncology (Northwood, London, England) [Med Oncol] 2024 Oct 14; Vol. 41 (11), pp. 271. Date of Electronic Publication: 2024 Oct 14.
DOI: 10.1007/s12032-024-02497-0
Abstrakt: The most prevalent form of primary liver cancer, hepatocellular carcinoma (HCC) poses a significant global health challenge due to its limited therapeutic options. Researchers are currently focused on the complex molecular landscape that governs the initiation and progression of HCC in order to identify new avenues for diagnosis, prognosis, and treatment. In the context of HCC, the Kinesin Superfamily Proteins (KIFs) have become critical regulators of cellular processes, prompting a growing interest in their function among the diverse array of molecular actors implicated in cancer. The KIFs, a family of microtubule-based molecular motors, are renowned for their essential roles in the dynamics of mitotic spindles and intracellular transport. Beyond their well-established functions in normal cellular physiology, emerging evidence indicates that dysregulation of KIFs significantly contributes to the pathogenesis of HCC. Novel therapeutic targets and diagnostic markers are revealed through the unique opportunity to comprehend the complex interplay between KIFs and the molecular events that drive HCC.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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