The Role of Parvalbumin Interneurons in Autism Spectrum Disorder.

Autor: Yao Y; Department of Central Laboratory, Shanghai Children's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China., Li Q; Department of Central Laboratory, Shanghai Children's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Jazyk: angličtina
Zdroj: Journal of neuroscience research [J Neurosci Res] 2024 Oct; Vol. 102 (10), pp. e25391.
DOI: 10.1002/jnr.25391
Abstrakt: As an important subtype of GABAergic interneurons, parvalbumin (PV) interneurons play a critical role in regulating cortical circuits and neural networks. Abnormalities in the development or function of PV interneurons have been linked to autism spectrum disorder (ASD), a neurodevelopmental disorder characterized by social and language deficits. In this review, we focus on the abnormalities of PV interneurons in ASD, including quantity and function and discuss the underlying mechanisms of impairments in PV interneurons in the pathology of ASD. Finally, we propose potential therapeutic approaches targeting PV interneurons, such as transplanting MGE progenitor cells and utilizing optogenetic stimulation in the treatment of ASD.
(© 2024 Wiley Periodicals LLC.)
Databáze: MEDLINE
Externí odkaz: