Multimodal functional imaging and clinical correlates of pain regions in chronic low-back pain patients treated with spinal cord stimulation: a pilot study.

Autor:	Shamli Oghli Y; Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, United States.; Jefferson Integrated Magnetic Resonance Imaging Center, Department of Radiology, Thomas Jefferson University, Philadelphia, PA, United States.; Department of Neurosurgery, Thomas Jefferson University, Philadelphia, PA, United States., Ashok A; Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, United States.; Jefferson Integrated Magnetic Resonance Imaging Center, Department of Radiology, Thomas Jefferson University, Philadelphia, PA, United States.; Department of Neurosurgery, Thomas Jefferson University, Philadelphia, PA, United States., Glener S; Department of Neurosurgery, Thomas Jefferson University, Philadelphia, PA, United States., Ailes I; Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, United States.; Jefferson Integrated Magnetic Resonance Imaging Center, Department of Radiology, Thomas Jefferson University, Philadelphia, PA, United States.; Department of Neurosurgery, Thomas Jefferson University, Philadelphia, PA, United States., Syed M; Jefferson Integrated Magnetic Resonance Imaging Center, Department of Radiology, Thomas Jefferson University, Philadelphia, PA, United States.; Department of Neurosurgery, Thomas Jefferson University, Philadelphia, PA, United States., Kang KC; Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, United States.; Jefferson Integrated Magnetic Resonance Imaging Center, Department of Radiology, Thomas Jefferson University, Philadelphia, PA, United States.; Department of Neurosurgery, Thomas Jefferson University, Philadelphia, PA, United States., Naghizadehkashani S; Jefferson Integrated Magnetic Resonance Imaging Center, Department of Radiology, Thomas Jefferson University, Philadelphia, PA, United States., Fayed I; Department of Neurosurgery, Cooper University Health Care, Camden, PA, United States., Mohamed FB; Jefferson Integrated Magnetic Resonance Imaging Center, Department of Radiology, Thomas Jefferson University, Philadelphia, PA, United States., Talekar K; Jefferson Integrated Magnetic Resonance Imaging Center, Department of Radiology, Thomas Jefferson University, Philadelphia, PA, United States., Krisa L; Jefferson Integrated Magnetic Resonance Imaging Center, Department of Radiology, Thomas Jefferson University, Philadelphia, PA, United States.; Department of Occupational Therapy, Thomas Jefferson University, Philadelphia, PA, United States., Wu C; Jefferson Integrated Magnetic Resonance Imaging Center, Department of Radiology, Thomas Jefferson University, Philadelphia, PA, United States.; Department of Neurosurgery, Thomas Jefferson University, Philadelphia, PA, United States., Matias C; Department of Neurosurgery, Thomas Jefferson University, Philadelphia, PA, United States., Alizadeh M; Jefferson Integrated Magnetic Resonance Imaging Center, Department of Radiology, Thomas Jefferson University, Philadelphia, PA, United States.; Department of Neurosurgery, Thomas Jefferson University, Philadelphia, PA, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in neuroimaging [Front Neuroimaging] 2024 Sep 27; Vol. 3, pp. 1474060. Date of Electronic Publication: 2024 Sep 27 (Print Publication: 2024).
DOI:	10.3389/fnimg.2024.1474060
Abstrakt:	Objective: Spinal cord stimulation (SCS) is an invasive treatment option for patients suffering from chronic low-back pain (cLBP). It is an effective treatment that has been shown to reduce pain and increase the quality of life in patients. However, the activation of pain processing regions of cLBP patients receiving SCS has not been assessed using objective, quantitative functional imaging techniques. The purpose of the present study was to compare quantitative resting-state (rs)-fMRI and arterial spin labeling (ASL) measures between SCS patients and healthy controls and to correlate clinical measures with quantitative multimodal imaging indices in pain regions. Methods: Multi-delay 3D GRASE pseudo-continuous ASL and rs-fMRI data were acquired from five patients post-SCS with cLBP and five healthy controls. Three ASL measures and four rs-fMRI measures were derived and normalized into MNI space and smoothed. Averaged values for each measure from a pain atlas were extracted and compared between patients and controls. Clinical pain scores assessing intensity, sensitization, and catastrophizing, as well as others assessing global pain effects (sleep quality, disability, anxiety, and depression), were obtained in patients and correlated with pain regions using linear regression analysis. Results: Arterial transit time derived from ASL and several rs-fMRI measures were significantly different in patients in regions involved with sensation (primary somatosensory cortex and ventral posterolateral thalamus [VPL]), pain input (posterior short gyrus of the insula [PS]), cognition (dorsolateral prefrontal cortex [DLPC] and posterior cingulate cortex [PCC]), and fear/stress response (hippocampus and hypothalamus). Unidimensional pain rating and sensitization scores were linearly associated with PS, VPL, DLPC, PCC, and/or amygdala activity in cLBP patients. Conclusion: The present results provide evidence that ASL and rs-fMRI can contrast functional activation in pain regions of cLBP patients receiving SCS and healthy subjects, and they can be associated with clinical pain evaluations as quantitative assessment tools. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. (Copyright © 2024 Shamli Oghli, Ashok, Glener, Ailes, Syed, Kang, Naghizadehkashani, Fayed, Mohamed, Talekar, Krisa, Wu, Matias and Alizadeh.)
Databáze:	MEDLINE
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