A multiscale inflammatory map: linking individual stress to societal dysfunction.
| Autor: | Vodovotz Y; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, United States.; Department of Immunology, Center for Systems Immunology, University of Pittsburgh, Pittsburgh, PA, United States., Arciero J; Department of Mathematical Sciences, Indiana University - Purdue University Indianapolis, Indianapolis, IN, United States., Verschure PF; Laboratory of Synthetic, Perceptive, Emotive and Cognitive Systems (SPECS), Donders Centre of Neuroscience, Donders Centre for Brain, Cognition and Behaviour, Faculty of Science and Engineering, Radboud University, Netherlands., Katz DL; Founder, True Health Initiative, The Health Sciences Academy, London, United Kingdom.; Tangelo Services, Auckland, United States. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in science [Front Sci] 2024; Vol. 1. Date of Electronic Publication: 2024 Mar 11. |
| DOI: | 10.3389/fsci.2023.1239462 |
| Abstrakt: | As populations worldwide show increasing levels of stress, understanding emerging links among stress, inflammation, cognition, and behavior is vital to human and planetary health. We hypothesize that inflammation is a multiscale driver connecting stressors that affect individuals to large-scale societal dysfunction and, ultimately, to planetary-scale environmental impacts. We propose a 'central inflammation map' hypothesis to explain how the brain regulates inflammation and how inflammation impairs cognition, emotion, and action. According to our hypothesis, these interdependent inflammatory and neural processes, and the inter-individual transmission of environmental, infectious, and behavioral stressors - amplified via high-throughput digital global communications - can culminate in a multiscale, runaway, feed-forward process that could detrimentally affect human decision-making and behavior at scale, ultimately impairing the ability to address these same stressors. This perspective could provide non-intuitive explanations for behaviors and relationships among cells, organisms, and communities of organisms, potentially including population-level responses to stressors as diverse as global climate change, conflicts, and the COVID-19 pandemic. To illustrate our hypothesis and elucidate its mechanistic underpinnings, we present a mathematical model applicable to the individual and societal levels to test the links among stress, inflammation, control, and healing, including the implications of transmission, intervention (e.g., via lifestyle modification or medication), and resilience. Future research is needed to validate the model's assumptions, expand the factors/variables employed, and validate it against empirical benchmarks. Our model illustrates the need for multilayered, multiscale stress mitigation interventions, including lifestyle measures, precision therapeutics, and human ecosystem design. Our analysis shows the need for a coordinated, interdisciplinary, international research effort to understand the multiscale nature of stress. Doing so would inform the creation of interventions that improve individuals' lives and communities' resilience to stress and mitigate its adverse effects on the world. Competing Interests: Conflict of interest statement: The authors declare a potential conflict of interest. YV is a co-founder of, and stakeholder in, Immunetrics, Inc. PV is the founder of and stakeholder in Eodyne Systems s.l. and Sapiens5 Holding BV. DLK was employed by Tangelo Services. Neither these companies nor the funders mentioned above were involved in the study funding, design, data collection, analysis, interpretation of data, the writing of this article, or the decision to submit it for publication. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. |
| Databáze: | MEDLINE |
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