Magnetic-vortex nanodonuts enhance ferroptosis effect of tumor ablation through an imaging-guided hyperthermia/radiosensitization strategy.

Autor:	Guo SS; Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450000, China., Chen MM; Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450000, China., Yang YH; Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450000, China., Zhang YY; Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450000, China., Pang X; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450000, China., Shi YP; Functional Magnetic Resonance and Molecular Imaging Key Laboratory of Henan Province, Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450000, China., Zhuang YC; Department of Imaging Sciences, University of Rochester Medical Center, Rochester, NY, USA., Fan DD; Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450000, China., Bao JF; Functional Magnetic Resonance and Molecular Imaging Key Laboratory of Henan Province, Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450000, China., Ji ZY; Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450000, China.
Jazyk:	angličtina
Zdroj:	IScience [iScience] 2024 Jul 18; Vol. 27 (10), pp. 110533. Date of Electronic Publication: 2024 Jul 18 (Print Publication: 2024).
DOI:	10.1016/j.isci.2024.110533
Abstrakt:	Pursuing more efficient multifunctional treatment is the main challenge of preclinical nanoparticle-mediated theranostics research. Here, nanoscale magnetite vortex donut shape was synthesized as a platform, and then ultrasmall gold nanoparticles were successfully embedded into the nanoring surface, thereby obtaining gold-modified magnetic vortex donut (GMVD). GMVD has a high photothermal conversion efficiency (η = 42.2%), which makes it have excellent photothermal ablation effect on tumors both in vivo and in vitro . Simultaneously, GMVD forms reactive oxygen species (ROS) under the 808 nm laser triggering, inducing ferroptosis. The addition of gold element also makes GMVD have the effect of radiotherapy (RT) sensitization. In conclusion, the synergistic treatment of RT and PTT greatly enhanced tumor ablation, indicating that GMVD has good biocompatibility and antitumor efficacy. This work demonstrates that the proposed GMVD can be a high-performance tumor diagnosis and theranostic treatment agent and may have great potential for clinical application in the future. Competing Interests: There are no conflicts to declare. (© 2024 The Authors.)
Databáze:	MEDLINE
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