Inhibition of hepatic stellate cell activation by nutraceuticals: an emphasis on mechanisms of action.

Autor: Sekar V; Department of Biochemistry, CSIR-Central Food Technological Research Institute, Mysore, Karnataka 570020 India., Vp V; Department of Biochemistry, CSIR-Central Food Technological Research Institute, Mysore, Karnataka 570020 India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002 India., Vijay V; Department of Biochemistry, CSIR-Central Food Technological Research Institute, Mysore, Karnataka 570020 India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002 India., Br A; Department of Biochemistry, CSIR-Central Food Technological Research Institute, Mysore, Karnataka 570020 India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002 India., Vijayan N; Department of Biochemistry, CSIR-Central Food Technological Research Institute, Mysore, Karnataka 570020 India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002 India., Perumal MK; Department of Biochemistry, CSIR-Central Food Technological Research Institute, Mysore, Karnataka 570020 India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002 India.
Jazyk: angličtina
Zdroj: Journal of food science and technology [J Food Sci Technol] 2024 Nov; Vol. 61 (11), pp. 2046-2056. Date of Electronic Publication: 2024 May 18.
DOI: 10.1007/s13197-024-06002-3
Abstrakt: Liver diseases emerge as a serious threat to humans worldwide due to increasing morbidity and mortality. Liver disease related deaths accounts for one third of all disease related death globally. A simple fatty liver if unattended advances further to liver fibrosis, cirrhosis and hepatocellular carcinoma. During liver fibrogenesis, hepatic stellate cells gets activated into myofibroblast like cells and exhibit proliferative and fibrogenic features. Targeting these activated hepatic stellate cells offer promising therapeutic approach towards liver fibrosis management. To date there is no Food and Drug Administration approved treatments for liver fibrosis. However, a large number of clinical trials are being conducted employing monoclonal antibodies, drugs, dietary supplements and herbal medicines. A vast number of research findings demonstrated nutraceuticals to be effective against experimental liver fibrosis both in vitro and in vivo. Nutraceuticals typically regulate key signaling pathways in activated hepatic stellate cells and exhibit anti-fibrotic effect. In this review, the mechanistic action of nutraceuticals targeting activated hepatic stellate cells were summarized to establish them as a possible therapeutic candidate for liver fibrosis.
Competing Interests: Conflict of interestThe authors declare no conflict of interest.
(© Association of Food Scientists & Technologists (India) 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.)
Databáze: MEDLINE
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