Hypersensitivity myocarditis induced by isoniazid overdose in a 15-year-old girl: a case report.

Autor:	Akçay N; Department of Pediatric Intensive Care Unit, University of Health Sciences Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey., Ateş B; Department of Pediatrics, University of Health Sciences Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey., Topal N; Department of Pediatrics, University of Health Sciences Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey., Bornaun H; Department of Pediatric Cardiology, University of Health Sciences Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey., Tosun D; Department of Pediatric Intensive Care Unit, University of Health Sciences Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey., Bingöl İ; Department of Pediatric Intensive Care Unit, University of Health Sciences Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey.
Jazyk:	angličtina
Zdroj:	Cardiology in the young [Cardiol Young] 2024 Oct 14, pp. 1-4. Date of Electronic Publication: 2024 Oct 14.
DOI:	10.1017/S1047951124026696
Abstrakt:	Introduction: Myocarditis represents a diverse group of inflammatory diseases affecting the heart muscle, with both infectious and non-infectious etiologies. Among the non-infectious causes, drug-induced hypersensitivity reactions are rare but serious. Isoniazid, a cornerstone in tuberculosis treatment, is known for its hepatotoxicity but has rarely been documented to cause hypersensitivity myocarditis. Case Report: We present a case of a 15-year-old girl from Eastern Turkmenistan who was admitted to our emergency department with altered consciousness and seizure activity. She was diagnosed with status epilepticus and treated accordingly. The patient, with no prior medical history, was found to have hypotensive shock and myocarditis upon further examination. A detailed history revealed she had ingested 45 tablets of expired isoniazid in a suicide attempt. She was treated with pyridoxine and supportive therapies, resulting in a gradual recovery. Conclusion: This case underscores the critical need to consider drug-induced hypersensitivity myocarditis in the differential diagnosis of myocarditis, especially in patients with recent medication use. Prompt recognition and appropriate treatment with pyridoxine, steroid, and supportive cardiac care can be lifesaving. This case also highlights the importance of awareness regarding the potential cardiotoxic effects of isoniazid overdose.
Databáze:	MEDLINE
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