Potential Player of Platelet in the Pathogenesis of Cardiotoxicity: Molecular Insight and Future Perspective.

Autor: Amin A; Department of Cardiology, School of Medicine, Shahid Madani Hospital, Lorestan University of Medical Sciences, Lorestan, Iran., Mohajerian A; Department of Emergency Medicine, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran., Ghalehnoo SR; Department of Cardiology, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran., Mohamadinia M; Department of Dental Prosthesis, School of Dentistry, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran., Ahadi S; School of Medicine, Jundishapur University of Medical Sciences, Ahvaz, Iran., Sohbatzadeh T; Student Research Committee, School of Medicine, Alborz University of Medical Science, Alborz, Iran., Pazoki M; Department of Cardiology, School of Medicine, Hazrat-E Rasool General Hospital, Iran University of Medical Sciences, Tehran, Iran., Hasanvand A; Department of General Surgery, Lorestan University of Medical Science, Khorramabad, Iran., Faghihkhorasani F; Xi'an Jiaotong University, Medical Campus, Xi'an, Shaanxi Province, China. ferdosfaghihkhorasani@gmail.com., Habibi Z; Lorestan University of Medical Science, Lorestan, Iran. zeinabhb98@gmail.com.
Jazyk: angličtina
Zdroj: Cardiovascular toxicology [Cardiovasc Toxicol] 2024 Oct 14. Date of Electronic Publication: 2024 Oct 14.
DOI: 10.1007/s12012-024-09924-8
Abstrakt: Cancer patients may encounter the onset of cardiovascular disease due to tumor advancement or chemotherapy, commonly known as "cardiotoxicity." In this respect, the conventional chemotherapy treatment protocol involves a mixture of different medications. These medications can be detrimental to cardiac tissue, consequently exposing the patient to the possibility of irreversible cardiac injury. The enhancement of oxidative stress and inflammation is an important mechanism of chemotherapeutic agents for developing cardiotoxicity. Regarding their dual pro- and anti-inflammatory functions, platelets can significantly influence the progression or suppression of cardiotoxicity. Therefore, the expression of platelet activatory markers can serve as valuable prognostic indicators for cardiotoxicity. The primary objective of this study is to examine the significance of platelets in cardiotoxicity and explore potential strategies that could effectively target malignant cells while minimizing their cytotoxic impact, such as cardiotoxicity and thrombosis.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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