Core outcome set for studies evaluating interventions to prevent or treat delirium in long-term care older residents: international key stakeholder informed consensus study.

Autor:	Russell G; Osprey House, Lynfield Mount Hospital, Bradford District Care NHS Foundation Trust, Heights Lane, Bradford BD9 6PD, United Kingdom., Rana N; City Hospital campus, Nottingham University Hospitals NHS Trust, Hucknall Rd, Nottingham NG5 1PB, United Kingdom., Reilly ST; Centre for Applied Dementia Studies, Faculty of Health Studies, University of Bradford, Richmond Rd, Bradford BD7 1DP, United Kingdom., Shehadeh A; Centre for Applied Dementia Studies, Faculty of Health Studies, University of Bradford, Richmond Rd, Bradford BD7 1DP, United Kingdom., Page V; Department of Critical Care, Watford General Hospital, Vicarage Rd, Watford, Hertfordshire WD18 0HB, United Kingdom., Siddiqi N; Department of Health Sciences, University of York-Medical School Siwards Way, Heslington, York YO10 5DD, United Kingdom., Rose L; Faculty of Nursing, Midwifery and Palliative Care, King's College London, 57 Waterloo Rd, London SE1 8WA, United Kingdom.
Jazyk:	angličtina
Zdroj:	Age and ageing [Age Ageing] 2024 Oct 01; Vol. 53 (10).
DOI:	10.1093/ageing/afae227
Abstrakt:	Background: Trials of interventions to prevent or treat delirium in older adults resident in long-term care settings (LTC) report heterogenous outcomes, hampering the identification of effective management strategies for this important condition. Our objective was to develop international consensus among key stakeholders for a core outcome set (COS) for future trials of interventions to prevent and/or treat delirium in this population. Methods: We used a rigorous COS development process including qualitative interviews with family members and staff with experience of delirium in LTC; a modified two-round Delphi survey; and virtual consensus meetings using nominal group technique. The study was registered with the Core Outcome Measures in Effectiveness Trials (COMET) initiative (https://www.comet-initiative.org/studies/details/796). Results: Item generation identified 22 delirium-specific outcomes and 32 other outcomes from 18 qualitative interviews. When combined with outcomes identified in our earlier systematic review, and following an item reduction step, this gave 43 outcomes that advanced to the formal consensus processes. These involved 169 participants from 12 countries, and included healthcare professionals (121, 72%), researchers (24, 14%), and family members/people with experience of delirium (24, 14%). Six outcomes were identified as essential to include in all trials of interventions for delirium in LTC, and were therefore included in the COS. These are: 'delirium occurrence'; 'delirium related distress'; 'delirium severity'; 'cognition including memory', 'admission to hospital' and 'mortality'. Conclusions: This COS, endorsed by the American Delirium Society and the European and Australasian Delirium Associations, is recommended for use in future clinical trials evaluating delirium prevention or treatment interventions for older adults residing in LTC. (© The Author(s) 2024. Published by Oxford University Press on behalf of the British Geriatrics Society.)
Databáze:	MEDLINE
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