Predicting frailty domain impairments and mortality with the Hospital Frailty Risk Score among older adults with cancer: the ELCAPA-EDS cohort study.

Autor:	Jean C; Université Paris-Est Créteil, Inserm, IMRB U955, Créteil, France.; Assistance Publique - Hôpitaux de Paris (AP-HP), Hôpital Henri-Mondor, Service Santé Publique & Unité de Recherche clinique, Créteil, France.; AP-HP, Chaire AI-RACLES, Paris, France., Paillaud E; Université Paris-Est Créteil, Inserm, IMRB U955, Créteil, France.; AP-HP, Hôpital Européen Georges Pompidou, Service de Gériatrie, Paris, France., Boudou-Rouquette P; AP-HP, Hôpital Cochin, Service d'Oncologie Médicale, Ariane program, Paris, France., Martinez-Tapia C; Université Paris-Est Créteil, Inserm, IMRB U955, Créteil, France.; Assistance Publique - Hôpitaux de Paris (AP-HP), Hôpital Henri-Mondor, Service Santé Publique & Unité de Recherche clinique, Créteil, France., Pamoukdjian F; AP-HP, Hôpital Avicenne, Service de Gériatrie, Bobigny, France., Hagège M; Université Paris-Est Créteil, Inserm, IMRB U955, Créteil, France., Bréant S; AP-HP, Pôle Innovation et Données, DSN, Paris, France., Hassen-Khodja C; AP-HP, Direction de la Recherche Clinique et de l'Innovation, Paris, France., Natella PA; Assistance Publique - Hôpitaux de Paris (AP-HP), Hôpital Henri-Mondor, Service Santé Publique & Unité de Recherche clinique, Créteil, France., Cudennec T; AP-HP, Hôpital Ambroise-Paré, Service de Gériatrie, Boulogne-Billancourt, France., Laurent M; Université Paris-Est Créteil, Inserm, IMRB U955, Créteil, France.; AP-HP, Hôpital Henri-Mondor, Service de Gériatrie et Médecine Interne, Créteil, France., Caillet P; Université Paris-Est Créteil, Inserm, IMRB U955, Créteil, France.; AP-HP, Hôpital Européen Georges Pompidou, Service de Gériatrie, Paris, France., Canouï-Poitrine F; Université Paris-Est Créteil, Inserm, IMRB U955, Créteil, France.; Assistance Publique - Hôpitaux de Paris (AP-HP), Hôpital Henri-Mondor, Service Santé Publique & Unité de Recherche clinique, Créteil, France., Audureau E; Université Paris-Est Créteil, Inserm, IMRB U955, Créteil, France.; Assistance Publique - Hôpitaux de Paris (AP-HP), Hôpital Henri-Mondor, Service Santé Publique & Unité de Recherche clinique, Créteil, France.; AP-HP, Chaire AI-RACLES, Paris, France.
Jazyk:	angličtina
Zdroj:	Age and ageing [Age Ageing] 2024 Oct 01; Vol. 53 (10).
DOI:	10.1093/ageing/afae222
Abstrakt:	Background: Automated frailty screening tools like the Hospital Frailty Risk Score (HFRS) are primarily validated for care consumption outcomes. We assessed the predictive ability of the HFRS regarding care consumption outcomes, frailty domain impairments and mortality among older adults with cancer, using the Geriatric 8 (G8) screening tool as a clinical benchmark. Methods: This retrospective, linkage-based study included patients aged ≥70 years with solid tumor, enrolled in the Elderly Cancer Patients (ELCAPA) multicentre cohort study (2016-2020) and hospitalized in acute care within the Greater Paris University Hospitals. HFRS scores, which encompass hospital-acquired problems and frailty-related syndromes, were calculated using data from the index admission and the preceding 6 months. A multidomain geriatric assessment (GA), including cognition, nutrition, mood, functional status, mobility, comorbidities, polypharmacy, incontinence, and social environment, was conducted at ELCAPA inclusion, with computation of the G8 score. Logistic and Cox regressions measured associations between the G8, HFRS, altered GA domains, length of stay exceeding 10 days, 30-day readmission, and mortality. Results: Among 587 patients included (median age 82 years, metastatic cancer 47.0%), 237 (40.4%) were at increased frailty risk by the HFRS (HFRS>5) and 261 (47.5%) by the G8 (G8≤10). Both HFRS and G8 were significantly associated with cognitive and functional impairments, incontinence, comorbidities, prolonged length of stay, and 30-day mortality. The G8 was associated with polypharmacy, nutritional and mood impairment. Discussion: Although showing significant associations with short-term care consumption, the HFRS could not identify polypharmacy, nutritional, mood and social environment impairments and showed low discriminatory ability across all GA domains. (© The Author(s) 2024. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
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