Assessing nanotoxicity of food-relevant particles: A comparative analysis of cellular responses in cell monolayers versus 3D gut epithelial cultures.
Autor: | Gautam A; School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore., Lim HK; Innovations in Food and Chemical Safety (IFCS) Programme, Agency for Science, Technology and Research, Singapore; Skin Research Institute of Singapore (SRIS), Agency for Science, Technology and Research, Singapore; Future Ready Food Safety Hub (a Joint Initiative of A∗STAR, SFA & NTU), Nanyang Technological University, Singapore., Li JJ; National Centre for Food Science, Singapore Food Agency, Singapore., Hughes CO; Innovations in Food and Chemical Safety (IFCS) Programme, Agency for Science, Technology and Research, Singapore; Skin Research Institute of Singapore (SRIS), Agency for Science, Technology and Research, Singapore; Future Ready Food Safety Hub (a Joint Initiative of A∗STAR, SFA & NTU), Nanyang Technological University, Singapore., Yeo CWS; National Centre for Food Science, Singapore Food Agency, Singapore., Rakshit M; School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore., Leavesley DI; Skin Research Institute of Singapore (SRIS), Agency for Science, Technology and Research, Singapore., Lim MJS; Future Ready Food Safety Hub (a Joint Initiative of A∗STAR, SFA & NTU), Nanyang Technological University, Singapore; Singapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science, Technology and Research, Singapore., Tan JCW; Future Ready Food Safety Hub (a Joint Initiative of A∗STAR, SFA & NTU), Nanyang Technological University, Singapore., Tan LY; School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore., Chan JSH; National Centre for Food Science, Singapore Food Agency, Singapore., Smith BPC; Innovations in Food and Chemical Safety (IFCS) Programme, Agency for Science, Technology and Research, Singapore; Future Ready Food Safety Hub (a Joint Initiative of A∗STAR, SFA & NTU), Nanyang Technological University, Singapore; Singapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science, Technology and Research, Singapore; Monell Chemical Senses Center, 3500 Market Street, Pennsylvania, 19104, USA. Electronic address: bsmith@monell.org., Ng KW; School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore; Skin Research Institute of Singapore (SRIS), Agency for Science, Technology and Research, Singapore; Nanyang Environment and Water Research Institute, Nanyang Technological University, 1 Cleantech Loop, CleanTech One, Singapore. Electronic address: kwng@ntu.edu.sg. |
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Jazyk: | angličtina |
Zdroj: | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2024 Oct 11; Vol. 193, pp. 115055. Date of Electronic Publication: 2024 Oct 11. |
DOI: | 10.1016/j.fct.2024.115055 |
Abstrakt: | Engineered nanoparticles (NPs) are extensively used in the food industry, yet safety concerns remain. The lack of validated methodologies is a bottleneck towards resolving this uncertainty. Hence, the current study aims to compare two cell models by examining the toxicological impacts of two food-relevant NPs (SiO Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have influenced the work reported in this paper. (Copyright © 2024 Elsevier Ltd. All rights reserved.) |
Databáze: | MEDLINE |
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