Acremochlorin S and other prenylated chlorophenol antimicrobial metabolites from the fungus Acremonium sp. Strain MNA-F-1.

Autor: Elnaggar MS; Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-Universität, 40225 Düsseldorf, Germany; Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, 11566 Cairo, Egypt., Mostafa NM; Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, 11566 Cairo, Egypt., Elissawy AM; Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, 11566 Cairo, Egypt; Center of Drug Discovery Research and Development, Ain Shams University, 11566 Cairo, Egypt., Phutthacharoen K; Center of Excellence in Fungal Research, Mae Fah Luang University, Chiang Rai 57100, Thailand; School of Science, Mae Fah Luang University, Chiang Rai 57100, Thailand., Eckhardt P; Department of Chemistry, Johannes Gutenberg University Mainz, Duesbergweg 10-14, 55128 Mainz, Germany., Sandargo B; Department of Microbial Drugs, Helmholtz Centre for Infection Research GmbH (HZI), 38124 Braunschweig, Germany., van Geelen L; Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-Universität, 40225 Düsseldorf, Germany., Ebada SS; Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, 11566 Cairo, Egypt. Electronic address: sherif.elsayed@helmholtz-hzi.de., Opatz T; Department of Chemistry, Johannes Gutenberg University Mainz, Duesbergweg 10-14, 55128 Mainz, Germany., Singab ANB; Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, 11566 Cairo, Egypt; Center of Drug Discovery Research and Development, Ain Shams University, 11566 Cairo, Egypt. Electronic address: vpr.nassersingab@pharma.asu.edu.eg., Kalscheuer R; Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-Universität, 40225 Düsseldorf, Germany. Electronic address: rainer.kalscheuer@uni-duesseldorf.de.
Jazyk: angličtina
Zdroj: Fitoterapia [Fitoterapia] 2024 Dec; Vol. 179, pp. 106254. Date of Electronic Publication: 2024 Oct 11.
DOI: 10.1016/j.fitote.2024.106254
Abstrakt: Chemical prospection for the mycelial extract of the fungus Acremonium sp. Strain MNA-F-1, derived from the inner tissue of anise roots (Pimpnella anisum L., family Apiaceae), led to the isolation and characterization of one previously undescribed natural product, acremochlorin S (1), together with five related derivatives (2-6) and an alkaloidal metabolite, ilicicolin H (7). Structure elucidation of the isolated compounds was determined through comprehensive 1D/2D NMR spectroscopic analyses and HR-ESI-MS measurements. The absolute configuration of acremochlorin S (1) was concluded based on the comparison of its experimental and calculated electronic circular dichroism (ECD) spectra implementing Time-dependent density functional theory (TDDFT). All isolated compounds were assessed for their antibacterial activity against Staphylococcus aureus, Escherichia coli and Mycobacterium tuberculosis, where several compounds revealed potent activities against tested Gram-positive strains.
Competing Interests: Declaration of competing interest The authors declare no competing interest.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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