Prevalence of high-risk human papillomavirus genotypes and viral load correlated with squamous cell inflammation among women in Gabon.

Autor: Mombo-Maganga C; National Public Health Laboratory, Libreville, Gabon.; Catholic University of Central Africa, Yaoundé, Cameroon., Mangala C; Institute of Infectious Diseases Professor Daniel Gahouma, Owendo, Gabon. imohu2004@yahoo.fr.; Catholic University of Central Africa, Yaoundé, Cameroon. imohu2004@yahoo.fr., Mabika-Obanda AKF; National Public Health Laboratory, Libreville, Gabon., Maulot-Bangola D; Institute of Infectious Diseases Professor Daniel Gahouma, Owendo, Gabon.; Catholic University of Central Africa, Yaoundé, Cameroon., Ambounda-Ledaga N; Anatomo-pathology Department of the Libreville University Hospital Center, Libreville, Gabon.; National Cancer Control Program in Gabon, Libreville, Gabon., Matsomo-Kombet GE; National Public Health Laboratory, Libreville, Gabon.; Catholic University of Central Africa, Yaoundé, Cameroon., Moukanda-Ifoundou R; Catholic University of Central Africa, Yaoundé, Cameroon.; Outpatient Treatment Center of Nkembo, Libreville, Gabon., Boukandou-Bina JA; Institute of Infectious Diseases Professor Daniel Gahouma, Owendo, Gabon.; Catholic University of Central Africa, Yaoundé, Cameroon., Obame-N'na L; Catholic University of Central Africa, Yaoundé, Cameroon.; Egyptian-Gabonese Cooperation Hospital, Libreville, Gabon., Tommo M; Chantal Biya International Reference Center, Yaoundé, Cameroon., Atenguena E; Oncology Department of the Yaounde General Hospital, Yaoundé, Cameroon.
Jazyk: angličtina
Zdroj: BMC women's health [BMC Womens Health] 2024 Oct 12; Vol. 24 (1), pp. 561. Date of Electronic Publication: 2024 Oct 12.
DOI: 10.1186/s12905-024-03403-6
Abstrakt: Background: High-risk genotypes of Human Papillomavirus are responsible for 90% of cases of cervical cancer worldwide. Inflammation of squamous cells is mainly linked to HPV. In Gabon, HPV is endemic and circulates among the female population. The study aimed to determine the prevalence of HR-HPV genotypes and to investigate the correlation between squamous cell inflammation and HPV viral load in infected women in Gabon.
Methods: The cross-sectional study was conducted at Libreville University Hospital Center (UHC) and National Public Health Laboratory from March to May 2024 among 399 women. Two cervical smears were taken. Genotype detection was carried out by multiplex fluorescence real-time PCR in the NPHL virology unit. Cytology was carried out in UHC's anatomic-pathology laboratory. Data were analyzed by SPSS software. Graphs were plotted using Microsoft Excel 2016.
Results: The prevalence of Human Papillomavirus was 26.1% (95% CI: 22-30.6). The prevalence of HR-HPV genotypes was 24.8%. The most common HR-HPV genotypes were HPV-16/52/18/35/56/58/53/68. The rate of multiple HPV infections was 29.8% and 95.2% for the HR-HPV infection rate. Viral load was significantly correlated with squamous cell inflammation (r = 0.977 and P = 0.001).
Conclusion: HR-HPV infection remains a concern in women, however early screening is necessary for optimal monitoring and management. HR-HPV viral load is a predictive marker of squamous cell inflammation.
(© 2024. The Author(s).)
Databáze: MEDLINE
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