Stochastic health risk assessment of aflatoxin M 1 in cow's milk among Lebanese population.

Autor: Dominguez S; Food Risk Analysis and Regulatory Excellence Platform (PARERA), Institute of Nutrition and Functional Foods and Department of Food Science, Université Laval, Quebec, (Quebec), G1V 0A6, Canada. Electronic address: silvia.dominguez.1@ulaval.ca., Théolier J; Food Risk Analysis and Regulatory Excellence Platform (PARERA), Institute of Nutrition and Functional Foods and Department of Food Science, Université Laval, Quebec, (Quebec), G1V 0A6, Canada., Daou R; Centre D'Analyses et de Recherche (CAR), Unité de Recherche Technologies et Valorisation Agro-Alimentaire (UR-TVA), Faculty of Sciences, Campus of Sciences and Technologies, Saint-Joseph University of Beirut, Mar Roukos P.O. Box 17-5208, Lebanon., Godefroy SB; Food Risk Analysis and Regulatory Excellence Platform (PARERA), Institute of Nutrition and Functional Foods and Department of Food Science, Université Laval, Quebec, (Quebec), G1V 0A6, Canada., Hoteit M; Food Sciences Unit, National Council for Scientific Research-Lebanon (CNRS-L), Beirut, Lebanon. Electronic address: maha.hoteit@cnrs.edu.lb., El Khoury A; Centre D'Analyses et de Recherche (CAR), Unité de Recherche Technologies et Valorisation Agro-Alimentaire (UR-TVA), Faculty of Sciences, Campus of Sciences and Technologies, Saint-Joseph University of Beirut, Mar Roukos P.O. Box 17-5208, Lebanon.
Jazyk: angličtina
Zdroj: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2024 Nov; Vol. 193, pp. 115042. Date of Electronic Publication: 2024 Oct 10.
DOI: 10.1016/j.fct.2024.115042
Abstrakt: This study quantitatively assessed AFM 1 exposure through consumption of cows' milk in Lebanese adolescents and adults. Lebanon-specific, non-aggregated data on (i) milk intake and body weight - from an existing survey for adults and from a new survey for adolescents, and (ii) AFM 1 occurrence in milk, were fitted to distributions and incorporated into a probabilistic model. Risk of hepatocellular carcinoma (HCC) for milk consumers was estimated considering the incidence of hepatitis B virus in Lebanon and characterized using the margin of exposure (MOE). All subgroups' mean risk estimates, expressed as additional HCC cases per 100 000 population per year, were significantly different (p < 0.05), and ranged from 2.2x10 -4 for adult males to 4.9x10 -4 for adolescent males. This variation is attributed to significant differences in body weight and milk intake. MOE identified adolescent males and females as at-risk populations (mean 9628 and 8108, respectively). For adults, levels of concern were only reached with extreme consumption and/or contamination events. Considering that exposure from other sources (e.g., dairy) is cumulative, control of AFM 1 in milk in Lebanon should be a risk management priority to ensure protection of younger populations.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Samuel B. Godefroy's research activities are funded by the Natural Sciences and Engineering Research Council of Canada; the U.S. Department of Agriculture Foreign Agriculture Service; R-Biopharm GmbH; and R-Biopharm Canada Inc. Samuel B. Godefroy acts as an expert advisor for members of the food and beverage industry, international organizations (the Food and Agriculture Organization of the United Nations, the United Nations Industrial Development Organization, and the World Bank), and international food regulators such as the China National Center for Food Safety Risk Assessment and consumer organizations such as Food Allergy Canada. Samuel Benrejeb Godefroy is the Board President of the Global Food Regulatory Science Society (GFoRSS). The other authors declare no competing interest. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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