Gestational exposure to organophosphate esters and autism spectrum disorder and other non-typical development in a cohort with elevated familial likelihood.

Autor: Choi JW; Department of Environmental Science, Baylor University, Waco, TX, USA. Electronic address: JeongWeon_Choi@baylor.edu., Oh J; Department of Public Health Sciences, University of California Davis, Davis, CA, USA., Bennett DH; Department of Public Health Sciences, University of California Davis, Davis, CA, USA., Kannan K; Division of Environmental Health Sciences, Wadsworth Center, New York State Department of Health, Albany, NY, USA., Tancredi DJ; Department of Pediatrics, University of California, Davis, Sacramento, CA, USA., Miller M; Department of Psychiatry & Behavioral Sciences, University of California, Davis, Sacramento, CA, USA., Schmidt RJ; Department of Public Health Sciences, University of California Davis, Davis, CA, USA; MIND Institute, University of California Davis, Sacramento, CA, USA., Shin HM; Department of Environmental Science, Baylor University, Waco, TX, USA.
Jazyk: angličtina
Zdroj: Environmental research [Environ Res] 2024 Dec 15; Vol. 263 (Pt 2), pp. 120141. Date of Electronic Publication: 2024 Oct 11.
DOI: 10.1016/j.envres.2024.120141
Abstrakt: Background: Gestational exposure to organophosphate esters (OPEs) is known to affect offspring neurodevelopment in animal studies. However, epidemiological evidence is inconsistent.
Methods: Participants were 277 mother-child pairs from MARBLES (Markers of Autism Risk in Babies - Learning Early Signs), a cohort with elevated familial likelihood of autism spectrum disorder (ASD). Nine OPE biomarker concentrations were quantified in maternal urine collected during the 2nd or 3rd trimesters of pregnancy. At age 3 years, children underwent clinical assessment for ASD and were classified into ASD, other non-typical development (non-TD), or typical development (TD). Multinomial logistic regression was used to estimate associations between each OPE biomarker and relative risk ratios for ASD and non-TD compared to TD. We examined effect modification by child sex and socioeconomic status. We also conducted a secondary analysis by using a continuous measure of ASD symptom severity as an outcome. Quantile-based g-computation was performed to examine the associations for an OPE mixture.
Results: Overall, no significant association was observed between the concentrations of each OPE biomarker or their mixture and relative risk for either ASD or non-TD. Effect modifications by child sex and maternal education were not observed. When the analysis was stratified by homeownership, among non-homeowners, ASD likelihood was increased with increased levels of bis(1-chloro-2-propyl) phosphate, bis(butoxyethyl) phosphate, and sum of di-n-butyl phosphate and di-iso-butyl phosphate (DBUP/DIBP) (p int < 0.10). Higher DBUP/DIBP were associated with increased ASD symptom severity scores.
Conclusion: There was no clear evidence of gestational OPE exposure in association with relative risk for ASD; however, potential effect modification by homeownership was observed. Although our cohort includes children with elevated familial likelihood of ASD, this is the first study investigating the association between gestational OPE exposure and clinically-diagnosed ASD. Further research is needed to confirm our findings in the general population.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Rebecca J. Schmidt reports a relationship with Beasley Allen Law Firm that includes: consulting or advisory and travel reimbursement. Rebecca J. Schmidt reports a relationship with Linus Biotechnology Inc. That includes: consulting or advisory and travel reimbursement. Rebecca J. Schmidt reports a relationship with Simons Foundation that includes: funding grants. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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