Study on cerebral oxygen saturation in children with sleep-disordered breathing.

Autor: Wu Y; School of Instrumentation Science and Optoelectronic Engineering, Beihang University, Beijing, China.; Department of Otolaryngology, Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China., Xu Z; Respiratory Department, Beijing Children's Hospital, Capital Medical University, China National Clinical Research Center of Respiratory Diseases, National Center for Children's Health, Beijing, China., Ge W; Department of Otolaryngology, Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China., Zhang X; Institute of Automation, Chinese Academy of Sciences, Beijing, China., Zheng L; Department of Otolaryngology, Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China., Ning X; School of Instrumentation Science and Optoelectronic Engineering, Beihang University, Beijing, China.; Key Laboratory of Ultra-Weak Magnetic Field Measurement Technology, Ministry of Education, School of Instrumentation and Optoelectronic Engineering, Beihang University, Beijing, China.; Institute of Large-Scale Scientific Facility and Centre for Zero Magnetic Field Science, Beihang University, Hangzhou, China.; National Institute of Extremely-Weak Magnetic Field Infrastructure, Hangzhou, China., Ni X; Department of Otolaryngology, Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Jazyk: angličtina
Zdroj: Journal of sleep research [J Sleep Res] 2024 Oct 12, pp. e14366. Date of Electronic Publication: 2024 Oct 12.
DOI: 10.1111/jsr.14366
Abstrakt: To explore the association between the severity of sleep-disordered breathing, different types of respiratory events, peripheral oxygen saturation (SpO 2 ), age and sleep stage on cerebral oxygen saturation (rSO 2 ) in children. We enrolled children aged 4-14 years who were treated for snoring or mouth breathing at the Sleep Center of Beijing Children's Hospital, from February 2022 to July 2022. All children completed polysomnography, and SpO 2 , rSO 2 , and heart rate (HR) were recorded synchronously. A total of 70 children were included, including 16 (22.9%) with primary snoring, 38 (54.3%) with mild obstructive sleep apnea (OSA), and 16 (22.9%) with moderate-to-severe OSA. There were no significant differences in the mean rSO 2 or minimum rSO 2 among the primary snoring, mild OSA, and moderate-to-severe OSA groups (all p > 0.05). A total of 1119 respiratory events were included in the analysis. Regardless of the type of respiratory event, rSO 2 and HR changes occur prior to fluctuations in SpO 2 . A mixed-effects model showed that ΔrSO 2 was positively correlated with ΔSpO 2 , duration of respiratory event, mixed and obstructive apnea, central apnea, while negatively correlated with age and rapid eye movement (REM) sleep stage (all p < 0.05). Larger rSO 2 fluctuations were impacted by a greater ΔSpO 2 , longer duration of respiratory events, younger age, apnea-related respiratory events and non-REM sleep stage. Thus, sleep disordered breathing in younger children warrants more attention. More research is needed to determine whether REM sleep has special protective effects on rSO 2 .
(© 2024 European Sleep Research Society. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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