Endoscopic prophylactic nipple-sparing mastectomy: First French survey of 10 patients.

Autor: Rathat G; Department of gynaecological and breast surgery, CHU Arnaud de Villeneuve, 371 Av. du Doyen Gaston Giraud, 34090 Montpellier, France. Electronic address: g-rathat@chu-montpellier.fr., Chaumette M; Department of gynaecological and breast surgery, CHU Arnaud de Villeneuve, 371 Av. du Doyen Gaston Giraud, 34090 Montpellier, France. Electronic address: maude_chaumette@orange.fr., Fontaine V; Department of gynaecological and breast surgery, CHU Arnaud de Villeneuve, 371 Av. du Doyen Gaston Giraud, 34090 Montpellier, France., Rebel L; Department of gynaecological and breast surgery, CHU Arnaud de Villeneuve, 371 Av. du Doyen Gaston Giraud, 34090 Montpellier, France. Electronic address: l-rebel@chu-montpellier.fr., Pissarra J; Clinical Research and Epidemiology Unit, Montpellier University Hospital, Univ Montpellier, Montpellier, France. Electronic address: joana.dasilvapissarra@chu-montpellier.fr., Duflos C; Clinical Research and Epidemiology Unit, Montpellier University Hospital, Univ Montpellier, Montpellier, France; IDESP, INSERM, Univ Montpellier, CHU Montpellier, Montpellier, France. Electronic address: c-duflos@chu-montpellier.fr., Duraes M; Department of gynaecological and breast surgery, CHU Arnaud de Villeneuve, 371 Av. du Doyen Gaston Giraud, 34090 Montpellier, France. Electronic address: m-duraes@chu-montpellier.fr.
Jazyk: angličtina
Zdroj: Journal of gynecology obstetrics and human reproduction [J Gynecol Obstet Hum Reprod] 2024 Oct 10; Vol. 54 (1), pp. 102862. Date of Electronic Publication: 2024 Oct 10.
DOI: 10.1016/j.jogoh.2024.102862
Abstrakt: Introduction: Current recommendations preconize prophylactic mastectomy for women over 30 with increased risk of breast cancer. Several surgical techniques are available to perform bilateral mastectomy with or without breast reconstruction. Our primary objective was to evaluate the feasibility of the Endoscopic Nipple Sparing Mastectomy (E-NSM) technique, without robotic assistance, using a single axillary incision and with immediate reconstruction using a prepectoral prosthesis in prophylactic indications. The secondary objectives were to evaluate the risks of postoperative complications and the esthetic results.
Material and Methods: This is a preliminary report of a prospective single-center interventional clinical study with a final enrolment target of 20 patients. The primary endpoint was the rate of complete surgical procedures per E-NSM. The secondary endpoints were the rate of conversions to conventional surgery, infections, hematomas, skin injury, pain and esthetic results (Breast-Q questionnaire, additional cosmetic procedures).
Results: From April 2019 to June 2022, 10 patients were included for 19 procedures (9 bilateral mastectomies, 1 unilateral). All surgical procedures were complete; no conversion to conventional surgery was required. The rate of complications per procedure requiring revision surgery was 16 % (1 skin necrosis, 1 postoperative hematoma and 1 surgical site infection). No prosthesis was removed. The seroma rate was 5 %. All patients would recommend this technique and were very satisfied or satisfied with the esthetic result. A second cosmetic procedure (lipofilling) was necessary in 50 % of patients.
Discussion: These preliminary data attest to the feasibility and safety of the E-NSM approach, and should be confirmed on a larger cohort and longer-term follow-up.
Gov Identifier: NCT03838549.
Competing Interests: Disclosure of interests The corresponding author is consultancy for Applied Medical, that's the only conflict of interest to disclose.
(Copyright © 2024. Published by Elsevier Masson SAS.)
Databáze: MEDLINE
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