Two bis-maltol-polyamines: Synthesis, characterization and studies of their palladium(II) complexes exploring their potential anticancer activity.

Autor: Paderni D; Department of Pure and Applied Sciences, University of Urbino, via Ca' Le Suore 2-4, 61029 Urbino, Italy., Macedi E; Department of Pure and Applied Sciences, University of Urbino, via Ca' Le Suore 2-4, 61029 Urbino, Italy. Electronic address: eleonora.macedi@uniurb.it., Sordini E; Molecular Pathology Laboratory 'PaoLa', Department of Biomolecular Sciences, University of Urbino Carlo Bo, Fano, PU, Italy., Amatori S; Molecular Pathology Laboratory 'PaoLa', Department of Biomolecular Sciences, University of Urbino Carlo Bo, Fano, PU, Italy., Rossi P; Department of Industrial Engineering, University of Florence, via S. Marta 3, 50139 Florence, Italy., Formica M; Department of Pure and Applied Sciences, University of Urbino, via Ca' Le Suore 2-4, 61029 Urbino, Italy., Giorgi L; Department of Pure and Applied Sciences, University of Urbino, via Ca' Le Suore 2-4, 61029 Urbino, Italy., Paoli P; Department of Industrial Engineering, University of Florence, via S. Marta 3, 50139 Florence, Italy., Fanelli M; Molecular Pathology Laboratory 'PaoLa', Department of Biomolecular Sciences, University of Urbino Carlo Bo, Fano, PU, Italy., Fusi V; Department of Pure and Applied Sciences, University of Urbino, via Ca' Le Suore 2-4, 61029 Urbino, Italy. Electronic address: vieri.fusi@uniurb.it.
Jazyk: angličtina
Zdroj: Journal of inorganic biochemistry [J Inorg Biochem] 2025 Jan; Vol. 262, pp. 112758. Date of Electronic Publication: 2024 Oct 09.
DOI: 10.1016/j.jinorgbio.2024.112758
Abstrakt: The interest in the antineoplastic and binding properties shown by the bis-maltol polyamine family, particularly Malten and Maltonis, prompted us to study the Pd 2+ complexes of these latter from both a biological and metallo-receptor point of view. The Malten-Pd 2+ complex can lodge hard species such as Sr 2+ in its coordination-driven preorganized pocket, as confirmed by X-ray diffraction. UV-Vis and NMR data showed that Malten-Pd 2+ forms even at acidic pH and exists in aqueous solution in a wide range of pH. The mononuclear complex is stable enough not to release Pd 2+ in solution for a long period of time (at least one week), thus Malten-Pd 2+ , similarly to Maltonis-Pd 2+ , is suitable to be tested in biological analyses. Studies on the U937 cell line revealed that the effect on cell survival reduction induced by Malten is partially lost in Malten-Pd 2+ , while no differences where monitored between the effects of Maltonis-Pd 2+ and Maltonis, suggesting that the availability of free maltol moieties, that is retained in Maltonis-Pd 2+ , but not in Malten-Pd 2+ , is crucial to guarantee the biological activity of these compounds.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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