Poly (ADP-ribose) Polymerase Inhibitor Resistance Driven by Emergence of Polyclonal Mutations With Convergent Evolution: A Molecular Tumor Board Discussion.

Autor: Fatteh M; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD.; The Johns Hopkins Molecular Tumor Board, Johns Hopkins University School of Medicine, Baltimore, MD., Wehr J; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD.; The Johns Hopkins Molecular Tumor Board, Johns Hopkins University School of Medicine, Baltimore, MD., Karaindrou K; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD.; The Johns Hopkins Molecular Tumor Board, Johns Hopkins University School of Medicine, Baltimore, MD., Xian RR; The Johns Hopkins Molecular Tumor Board, Johns Hopkins University School of Medicine, Baltimore, MD.; Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD., Gocke C; The Johns Hopkins Molecular Tumor Board, Johns Hopkins University School of Medicine, Baltimore, MD.; Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD., Lin MT; The Johns Hopkins Molecular Tumor Board, Johns Hopkins University School of Medicine, Baltimore, MD.; Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD., Petry D; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD.; The Johns Hopkins Molecular Tumor Board, Johns Hopkins University School of Medicine, Baltimore, MD., Visvanathan K; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD.; The Johns Hopkins Molecular Tumor Board, Johns Hopkins University School of Medicine, Baltimore, MD., Couzi R; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD.; The Johns Hopkins Molecular Tumor Board, Johns Hopkins University School of Medicine, Baltimore, MD., Santa Maria C; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD., Stearns V; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD., Tao JJ; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD.; The Johns Hopkins Molecular Tumor Board, Johns Hopkins University School of Medicine, Baltimore, MD., Anagnostou V; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD.; The Johns Hopkins Molecular Tumor Board, Johns Hopkins University School of Medicine, Baltimore, MD., Canzoniero JV; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD.; The Johns Hopkins Molecular Tumor Board, Johns Hopkins University School of Medicine, Baltimore, MD.
Jazyk: angličtina
Zdroj: JCO precision oncology [JCO Precis Oncol] 2024 Oct; Vol. 8, pp. e2400254. Date of Electronic Publication: 2024 Oct 11.
DOI: 10.1200/PO.24.00254
Abstrakt: Polyclonal convergent evolution to PARPi resistance in a patient with metastatic breast cancer with gPALB2.
Databáze: MEDLINE