Features of Swallowing Function in Sporadic Inclusion Body Myositis: Preliminary Evidence Using Well-Tested Assessment Frameworks.

Autor: Ambrocio KR; Department of Communication Science and Disorders, School of Health and Rehabilitation Sciences, University of Pittsburgh, PA., Aggarwal R; Myositis Center, University of Pittsburgh Medical Center, PA.; Division of Rheumatology and Clinical Immunology, School of Medicine, University of Pittsburgh, PA., Lacomis D; Muscular Dystrophy Association Care Center, University of Pittsburgh Medical Center, PA.; Division of Neurology and Pathology (Neuropathology), School of Medicine, University of Pittsburgh, PA., Zhang X; Department of Communication Science and Disorders, School of Health and Rehabilitation Sciences, University of Pittsburgh, PA., Garand KLF; Department of Communication Science and Disorders, School of Health and Rehabilitation Sciences, University of Pittsburgh, PA.; Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Medical University of South Carolina, Charleston (Adjunct affiliation).
Jazyk: angličtina
Zdroj: American journal of speech-language pathology [Am J Speech Lang Pathol] 2024 Nov 04; Vol. 33 (6), pp. 2793-2804. Date of Electronic Publication: 2024 Oct 11.
DOI: 10.1044/2024_AJSLP-24-00061
Abstrakt: Purpose: Evidence surrounding swallowing impairment in sporadic inclusion body myositis (IBM) is based on nonstandardized and nonvalidated assessment methods. We investigated (a) IBM's impact on swallowing function and oral intake status using well-tested assessment frameworks; (b) changes in swallowing over time; and (c) age, sex, and swallowing impairment severity's influence on oral intake status.
Method: We conducted a secondary analysis of Modified Barium Swallow Impairment Profile (MBSImP) and Functional Oral Intake Scale (FOIS) data from 13 patients with IBM (seven females; M age = 60.2 [±13.6] years) and 13 age- and sex-matched healthy controls. We compared MBSImP Overall Impression (OI), Oral Total (OT), Pharyngeal Total (PT), and FOIS scores between groups. Specific to the IBM cohort, we analyzed repeated OT and PT scores and calculated whether age, sex, and OT and PT scores predicted FOIS scores.
Results: The IBM cohort demonstrated poorer OI scores across six swallowing components than healthy controls (each p < .05). Unlike OT scores ( p = .84), PT ( p = .033) and FOIS ( p < .001) scores were worse in the IBM cohort. Repeated OI scores revealed changes in three swallowing components (each p < .05), but repeated OT ( p = .16) and PT ( p = .30) scores did not significantly change. Age, sex, and OT and PT scores did not influence FOIS scores (each p > .05).
Conclusions: Pharyngeal impairments were most prominent in the IBM cohort, and their oral intake status was adversely affected. Our preliminary data showcase the application of robust assessment methods to investigate swallowing function in IBM, enhancing standardization and comparability across studies.
Supplemental Material: https://doi.org/10.23641/asha.27165450.
Databáze: MEDLINE
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