The endoplasmic reticulum as an active liquid network.

Autor:	Scott ZC; Department of Physics, University of California, San Diego, La Jolla, CA 92093., Steen SB; Department of Chemistry and Biochemistry, Calvin University, Grand Rapids, MI 49546., Huber G; Chan Zuckerberg Biohub-San Francisco, San Francisco, CA 94158., Westrate LM; Department of Chemistry and Biochemistry, Calvin University, Grand Rapids, MI 49546., Koslover EF; Department of Physics, University of California, San Diego, La Jolla, CA 92093.
Jazyk:	angličtina
Zdroj:	Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Oct 15; Vol. 121 (42), pp. e2409755121. Date of Electronic Publication: 2024 Oct 11.
DOI:	10.1073/pnas.2409755121
Abstrakt:	The peripheral endoplasmic reticulum (ER) forms a dense, interconnected, and constantly evolving network of membrane-bound tubules in eukaryotic cells. While individual structural elements and the morphogens that stabilize them have been described, a quantitative understanding of the dynamic large-scale network topology remains elusive. We develop a physical model of the ER as an active liquid network, governed by a balance of tension-driven shrinking and new tubule growth. This minimalist model gives rise to steady-state network structures with density and rearrangement timescales predicted from the junction mobility and tubule spawning rate. Several parameter-independent geometric features of the liquid network model are shown to be representative of ER architecture in live mammalian cells. The liquid network model connects the timescales of distinct dynamic features such as ring closure and new tubule growth in the ER. Furthermore, it demonstrates how the steady-state network morphology on a cellular scale arises from the balance of microscopic dynamic rearrangements. Competing Interests: Competing interests statement:The authors declare no competing interest.
Databáze:	MEDLINE
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