Bioactive surface modifications on dental implants: a systematic review and meta-analysis of osseointegration and longevity.

Autor: Shayeb MA; Department of Clinical Sciences, College of Dentistry, Center of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman, UAE. m.alshayeb@ajman.ac.ae., Elfadil S; Department of Clinical Sciences, College of Dentistry, Center of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman, UAE., Abutayyem H; Department of Clinical Sciences, College of Dentistry, Center of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman, UAE., Shqaidef A; Department of Clinical Sciences, College of Dentistry, Center of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman, UAE.; Department of Paediatric Dentistry and Orthodontics, Faculty of Dentistry, University of Jordan, Amman, Jordan., Marrapodi MM; Department of Woman, Child and General and Specialist Surgery, University of Campania 'Luigi Vanvitelli', Naples, 80121, Italy. mariamaddalena.marrapodi@studenti.unicampania.it., Cicciù M; Department of Biomedical and Surgical and Biomedical Sciences, Catania University, Catania, 95123, Italy., Minervini G; Multidisciplinary Department of Medical-Surgical and Odontostomatological Specialties, University of Campania 'Luigi Vanvitelli', Naples, 80121, Italy. giuseppe.minervini@unicampania.it.; Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, Tamil Nadu, India. giuseppe.minervini@unicampania.it.
Jazyk: angličtina
Zdroj: Clinical oral investigations [Clin Oral Investig] 2024 Oct 11; Vol. 28 (11), pp. 592. Date of Electronic Publication: 2024 Oct 11.
DOI: 10.1007/s00784-024-05958-y
Abstrakt: Background: Bioactive surface modifications have been proposed to enhance osseointegration and longevity of dental implants. This study aimed to systematically review and perform a meta-analysis on the effectiveness of various bioactive coatings in promoting bone integration and improving implant longevity.
Methods: A systematic review was conducted, including studies that investigated bioactive surface modifications on titanium dental implants. Outcomes of interest were bone-to-implant contact (BIC) and implant longevity over a 30-day period. Data were extracted and analyzed using RevMan 5 (version 5.4.1), with forest plots generated to represent the mean difference (MD) and 95% confidence intervals (CI) under a random effects model.
Results: The meta-analysis showed a significant improvement in BIC for surface-modified implants, with an overall MD of 7.29 (95% CI [2.94, 11.65]). Heterogeneity analysis indicated moderate heterogeneity (Tau² = 18.57, Chi² = 16.08, df = 8, P = 0.04, I² = 50%). The test for overall effect yielded Z = 3.28 (P = 0.001). For implant longevity, the overall MD was 7.52 (95% CI [3.18, 11.85]), with moderate heterogeneity (Tau² = 17.28, Chi² = 14.95, df = 8, P = 0.06, I² = 47%). The test for overall effect yielded Z = 3.40 (P = 0.0007).
Conclusion: Bioactive surface changes significantly improved osseointegration and lifespan of dental implants. Collagen-based coatings consistently encouraged early bone integration, while BMP-2 combinations were effective for osseointegration. Optimizing bioactive agent doses and combinations was critical for achieving desired outcomes.
(© 2024. The Author(s).)
Databáze: MEDLINE
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