Enhancing Efficiency and Sustainability: Unleashing the Potential of Continuous Flow in Multicomponent Reactions.

Autor: Carvalho MHR; Universidade Federal de Juiz de Fora, Chemistry, BRAZIL., de Castro PP; Universidade Federal de Juiz de Fora - Campus GV, Pharmacy, BRAZIL., de Oliveira KT; Universidade Federal de São Carlos, Chemistry, BRAZIL., Amarante GW; Universidade Federal de Juiz de Fora, Chemistry, Rua José Lourenço Kelmer, s/n,, São Pedro, 36036-900, Juiz de Fora, BRAZIL.
Jazyk: angličtina
Zdroj: ChemSusChem [ChemSusChem] 2024 Oct 11, pp. e202401840. Date of Electronic Publication: 2024 Oct 11.
DOI: 10.1002/cssc.202401840
Abstrakt: The integration of multicomponent reactions (MCRs), which offer a rapid and efficient approach to synthesize complex molecular scaffolds, with continuous flow platforms is an increasingly recognized strategy in green synthesis. This association enables precise control over reaction parameters, including improved kinetics and selectivity, reduced reaction times, enhanced yields and scalabilities, while aligning with sustainable and green chemistry principles through resource utilization, minimized waste, and reduced environmental impact. This review presents a critical analysis of recent studies covering the MCR-continuous flow association, with a focus on achieving greener and more sustainable synthesis practices.
(© 2024 Wiley‐VCH GmbH.)
Databáze: MEDLINE
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