Unmasking bocavirus: is it a co-infectious agent or an actual respiratory pathogen?

Autor:	Hanalioglu D; Pediatric Emergency Clinic, Ankara Bilkent City Hospital, Ankara, Türkiye.; Department of Pediatrics, Division of Pediatric Emergency, University of Health Sciences, Ankara, Türkiye., Cetin S; Pediatric Emergency Clinic, Ankara Bilkent City Hospital, Ankara, Türkiye., Cetin M; Pediatric Emergency Clinic, Ankara Bilkent City Hospital, Ankara, Türkiye., Dinc B; Department of Microbiology, Ankara Bilkent City Hospital, Ankara, Türkiye., Akcan Yildiz L; Pediatric Emergency Clinic, Ankara Bilkent City Hospital, Ankara, Türkiye.; Department of Pediatrics, Division of Pediatric Emergency, Hacettepe University, Ankara, Türkiye., Kaynak MO; Pediatric Emergency Clinic, Ankara Bilkent City Hospital, Ankara, Türkiye., Kurt F; Pediatric Emergency Clinic, Ankara Bilkent City Hospital, Ankara, Türkiye.; Department of Pediatrics, Division of Pediatric Emergency, University of Health Sciences, Ankara, Türkiye., Akca H; Pediatric Emergency Clinic, Ankara Bilkent City Hospital, Ankara, Türkiye.; Pediatric Emergency Department, Ankara Yildirim Beyazit University, Ankara, Türkiye., Senel S; Pediatric Emergency Clinic, Ankara Bilkent City Hospital, Ankara, Türkiye.; Pediatric Emergency Department, Ankara Yildirim Beyazit University, Ankara, Türkiye., Karacan CD; Pediatric Emergency Clinic, Ankara Bilkent City Hospital, Ankara, Türkiye.; Pediatric Emergency Department, Ankara Yildirim Beyazit University, Ankara, Türkiye.
Jazyk:	angličtina
Zdroj:	Postgraduate medicine [Postgrad Med] 2024 Nov; Vol. 136 (8), pp. 864-874. Date of Electronic Publication: 2024 Oct 15.
DOI:	10.1080/00325481.2024.2412972
Abstrakt:	Objectives: Although human bocavirus (HBoV) is primarily linked to respiratory tract infections, its exact role as a respiratory pathogen remains unclear. This study aims to investigate HBoV detection rates, as well as clinical, laboratory, microbiological, and radiological characteristics, length of stay in the emergency department (ED), rate of hospitalization, and severity of illness in cases where HBoV is detected in respiratory secretions. Methods: We conducted a retrospective analysis of all consecutive patients under 18 years who visited a large-volume tertiary pediatric ED from January to December 2023 and tested positive for HBoV in their respiratory viral panel (RVP). Results: Among the 14,315 patients who underwent RVP testing during the study period, 591 (4%) tested positive for HBoV. After excluding those with incomplete data, 528 patients (57% male) were included in the analyses. The median age was 2.8 [1.2-4.9] years. The most common symptoms were cough (67%), fever (58%), runny nose/nasal congestion/sore throat (34%), and respiratory distress (24%). Thirty percent of the patients had a history of antibiotic use before admission. Thirteen percent of the patients had at least one chronic illness. Co-infection with HBoV occurred in 37% of the patients, with respiratory syncytial virus (RSV) being the most frequently co-detected virus (45%). Lymphopenia was documented in 12% of patients, and 36% had elevated C-reactive protein levels (median 21 [12-38] g/dl). Abnormal chest X-rays were noted in 85% of patients. The management approach included outpatient care for more than half of the patients (69%). Clinical severity was classified as high in 11% of patients ( n  = 60), necessitating ICU admission. Conclusion: Although typically mild, HBoV infections can escalate to severe respiratory illnesses, requiring respiratory support and intensive care.
Databáze:	MEDLINE
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