Nutritional and potential health benefits of chufa oil, olive oil, and anhydrous milk fat against gallstone disease in a C57BL/6N mouse model.

Autor:	Zommara MA; Department of Dairy Science, Faculty of Agriculture, Kafrelsheikh University, Kafr El-Sheikh, Egypt., Swelam S; Department of Dairy Science, Faculty of Agriculture, Kafrelsheikh University, Kafr El-Sheikh, Egypt., Raya-Álvarez E; Department of Rheumatology, Hospital Universitario San Cecilio, Granada, Spain., Imaizumi K; Laboratory of Nutrition Chemistry, Division of Bioresource and Bioenvironmental Sciences, Graduate School, Kyushu University, Fukuoka, Japan., Elmahdy A; Department of Dairy Science, Faculty of Desert and Environmental Agriculture, Matrouh University, Matrouh, Egypt., Alkhudhayri DA; Department of Home Economics, Prince Sattam Bin Abdul Aziz University, Al-Kharj, Saudi Arabia., Aljehani AA; Department of Food and Nutrition, Faculty of Human Sciences and Design, King Abdulaziz University, Jeddah, Saudi Arabia., Agil A; Department of Pharmacology, School of Medicine, Biohealth Institute Granada (IBs Granada) and Neuroscience Institute, University of Granada, Granada, Spain., Elmahallawy EK; Grupo de Investigación en Sanidad Animal y Zoonosis (GISAZ), Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad de Córdoba, Córdoba, Spain.; Department of Zoonoses, Faculty of Veterinary Medicine, Sohag University, Sohag, Egypt.
Jazyk:	angličtina
Zdroj:	Frontiers in nutrition [Front Nutr] 2024 Sep 26; Vol. 11, pp. 1445484. Date of Electronic Publication: 2024 Sep 26 (Print Publication: 2024).
DOI:	10.3389/fnut.2024.1445484
Abstrakt:	Dietary lipids play a major role in many diseases, particularly cardiovascular diseases. Recently, the health value of plant oils, particularly heart health, has been recognized. Despite these facts, limited information is available on the potential nutritional and anti-arteriolosclerosis effects of chufa oil, olive oil, and anhydrous milk fat in C57BL/6N mice. In the present study, the effects of olive oil (OO), chufa oil (CO), and anhydrous milk fat (AMF) on 4-week-old C57BL/6N male mice, a model for studies of diet-induced atherosclerosis, were investigated. The AIN-93G-based diet was supplemented with 15% of either OO, CO, or AMF. The final mixture of the diets contained 15% fat, approximately 1.25% cholesterol, and 0.5% sodium cholate. The data obtained showed that most mice had gallstone disease. The highest percentage of the gallstones formed were found in AMF groups (approximately 85.7% of the mice). However, the lowest one was found in the chufa oil group (42.9%), followed by the olive oil group (57.1%). Although the mice's food intake significantly differed, their body weights did not change during the feeding period. The diet supplemented with CO resulted in a significant reduction in serum cholesterol compared with the other groups. Livers from the CO-fed group showed higher triglyceride levels than those from the AMF group. No significant differences were found in atherosclerotic lesions in the aortic valve between the groups. Collectively, our results show no deleterious nutritional effects of the fats used on C57BL/6N mice fed cholesterol-rich diets. Chufa oil improved cholesterol metabolism and atherogenic index in mice. However, the major issue is the formation of gallstones in all mice, which is most prominent in AMF, followed by olive oil and chufa oil diets. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Zommara, Swelam, Raya-Álvarez, Imaizumi, Elmahdy, Alkhudhayri, Aljehani, Agil and Elmahallawy.)
Databáze:	MEDLINE
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