Population data for 12 X-STRs loci in Malaysian Malay and Chinese populations.

Autor: Alwi AR; Department of Biosciences, Faculty of Science, Universiti Teknologi Malaysia (UTM), 81310 Johor Bahru, Johor, Malaysia.; Department of Chemistry Malaysia Johor State, Jalan Abdul Samad, 80100 Johor Bahru, Johor, Malaysia., Mahat NA; Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia (UTM), 81310 Johor Bahru, Johor, Malaysia.; Investigative and Forensic Sciences Research Group, Universiti Teknologi Malaysia (UTM), 81310 Johor Bahru, Johor, Malaysia.; Centre for Sustainable Nanomaterials, Ibnu Sina Institute for Scientific and Industrial Research, Universiti Teknologi Malaysia (UTM), 81310 Johor Bahru, Johor, Malaysia.; Centre of Research for Fiqh Forensics and Judiciary, Faculty of Syariah and Law, Universiti Sains Islam Malaysia (USIM), Bandar Baru Nilai, 71800, Nilai, Negeri Sembilan, Malaysia., Salleh FM; Department of Biosciences, Faculty of Science, Universiti Teknologi Malaysia (UTM), 81310 Johor Bahru, Johor, Malaysia.; Investigative and Forensic Sciences Research Group, Universiti Teknologi Malaysia (UTM), 81310 Johor Bahru, Johor, Malaysia., Ishar SM; Forensic Science Program, Faculty of Health Sciences, Universiti Kebangsaan Malaysia (UKM), 43600 Bangi, Selangor, Malaysia., Kamaluddin MR; Centre for Research in Psychology and Human Well-Being, Faculty of Social Sciences and Humanities, Universiti Kebangsaan Malaysia (UKM), 43600 Bangi, Selangor, Malaysia., Rashid MRA; Family Medicine Unit, Faculty of Medicine and Health Science, Universiti Sains Islam Malaysia (USIM), Bandar Baru Nilai, 71800, Nilai, Negeri Sembilan, Malaysia., Rahayu Karmilla Syed Hassan SN; Faculty of Medicine, Universiti Sultan Zainal Abidin (UniSZA), Medical Campus, 20400 Kuala Terengganu, Terengganu, Malaysia., Iyavoo S; School of Natural Sciences, College of Health and Science, University of Lincoln, Lincoln, United Kingdom.
Jazyk: angličtina
Zdroj: Heliyon [Heliyon] 2024 Sep 18; Vol. 10 (19), pp. e38054. Date of Electronic Publication: 2024 Sep 18 (Print Publication: 2024).
DOI: 10.1016/j.heliyon.2024.e38054
Abstrakt: The utilization of X-chromosome short tandem repeats (X-STRs) for human identification particularly in resolving complex kinship cases has been advocated. Since, forensic statistical parameters vary among different populations, and because the X-STRs population data representing the diverse population of Peninsular Malaysia remain unavailable, the specific attempt reported here for the Malays (n = 224) and Chinese (n = 201) populations appears forensically relevant to support the evidential value of the 12 X-STRs markers for human identification in Malaysia. Results derived from the Qiagen Investigator® Argus X-12 kit revealed that DXS10135 as the most polymorphic locus with high genetic diversity, polymorphic information content, heterozygosity as well as power of exclusion. Based on allele frequencies, the combined power of discrimination as well as the mean exclusion chance (MEC Krüger , MEC Kishida , MEC Desmarais and MEC DesmaraisDuo ) values for the Malays and Chinese were individually ≥0.999995532964908. As for the combined power of discrimination as well as the mean exclusion chance (MEC Krüger , MEC Kishida , MEC Desmarais and MEC DesmaraisDuo ) calculated based on haplotype frequencies, the values were ≥0.9999986410567 for the Malays and Chinese populations. In addition, results from the genetic distance, neighbor-joining phylogenetic tree and principal component analysis revealed close biogeographical distributions of the studied populations with other South East Asian populations. Hence, the utilization of the X-STRs data for identifying individuals among the Malays and Chinese populations in Peninsular Malaysia for forensic application appears as highly supported.
Competing Interests: The authors declare no conflicts of interest.
(© 2024 The Authors.)
Databáze: MEDLINE
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