Biochemical, toxicological, and microbiological assessment of calcined poultry manure for potential use as bone scaffold material.

Autor:	Alaneme KK; Materials Design and Structural Integrity Group, Department of Metallurgical and Materials Engineering, The Federal University of Technology Akure, P.M.B. 704, Ondo State, Nigeria.; Centre for Nanoengineering and Advanced Materials, School of Mining, Metallurgy and Chemical Engineering, Faculty of Engineering & the Built Environment, University of Johannesburg, South Africa., Fagbayi SB; Materials Design and Structural Integrity Group, Department of Metallurgical and Materials Engineering, The Federal University of Technology Akure, P.M.B. 704, Ondo State, Nigeria., Nwanna EE; Department of Biochemistry, The Federal University of Technology Akure, P.M.B. 704, Ondo State, Nigeria., Ojo OM; Department of Civil and Environmental Engineering, The Federal University of Technology Akure, P.M.B. 704, Ondo State, Nigeria.
Jazyk:	angličtina
Zdroj:	Heliyon [Heliyon] 2024 Sep 24; Vol. 10 (19), pp. e38378. Date of Electronic Publication: 2024 Sep 24 (Print Publication: 2024).
DOI:	10.1016/j.heliyon.2024.e38378
Abstrakt:	The biosafety of thermally calcined poultry manure as a hydroxyapatite source for potential use as bone-making material was investigated in this study. In vitro assays were used to determine the sensitivity of the antioxidant properties to the thermal calcination temperature used to process the poultry manure (750, 800, and 850 °C ). The effect of the extract of both calcined poultry manure (local) and analytical grade hydroxyapatite (foreign) at various concentrations of 100%-25 % inclusion at (100 mg/kg) body weight intubation for 21 days on kidney, liver, and serum of animal model used was assessed. The results show that the thermally calcined poultry manure-derived hydroxyapatite generally possessed good antioxidant properties with the poultry manure treated at 750 °C having the most promising antioxidant properties compared to those treated at 800 and 850 °C , and hence a more likely improved anti-toxicity potential. The various blends of the analytical high-grade hydroxyapatite and thermally calcined poultry manure hydroxyapatite samples are safe compared to the normal control rats with regards hepatic function and renal function parameters with the equal blend of analytical high grade and thermally calcined poultry manure-derived hydroxyapatite (1:1) possessing the lowest activity concentrations. In addition, the enzymatic (glutathione peroxidase) and non-enzymatic (reduced glutathione) antioxidant concentrations of the experimental animals administered the varied compositions of the analytical high grade and thermally calcined poultry manure-derived hydroxyapatite, were lower when compared to normal control rats. The microbiological evaluation suggests that the calcined poultry manure inclusion at various concentrations could not pose a negative effect on various pathology in the liver, kidney, and blood. Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Kenneth Alaneme reports financial support was provided by Tertiary Education Trust Fund. Kenneth Alaneme reports article publishing charges was provided by National Research Fund. None If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2024 The Authors.)
Databáze:	MEDLINE
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