| Autor: |
Luo LF; College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, China., Tian MM; College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, China., Wu JC; College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, China. |
| Jazyk: |
angličtina |
| Zdroj: |
Natural product research [Nat Prod Res] 2024 Oct 11, pp. 1-8. Date of Electronic Publication: 2024 Oct 11. |
| DOI: |
10.1080/14786419.2024.2413034 |
| Abstrakt: |
A new protoberberine type alkaloid, 11-diethylaminomethyl corydalmine ( 1 ), and 27 known alkaloids ( 2 - 28 ) were isolated from the tuberous roots of Stephania cephalantha . Their structures were identified by spectral analysis. Enzyme inhibitory activities of the compounds on acetylcholinesterase (AChE), tyrosinase and α-glucosidase were evaluated. Compounds 13 , 16 and 18 exhibited comparable AChE inhibitory activities to the positive control huperzine A, with the IC 50 values of 0.046, 0.048, and 0.057 mg/mL, respectively. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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