White matter alterations associated with chronic cannabis use disorder: a structural network and fixel-based analysis.

Autor: Maleki S; BrainPark, Turner Institute for Brain and Mental Health, School of Psychological Sciences and Monash Biomedical Imaging Facility, Monash University, Clayton, VIC, Australia., Hendrikse J; Movement and Exercise Neuroscience Laboratory, School of Psychological Sciences and Monash Biomedical Imaging Facility, Monash University, Clayton, VIC, Australia., Richardson K; BrainPark, Turner Institute for Brain and Mental Health, School of Psychological Sciences and Monash Biomedical Imaging Facility, Monash University, Clayton, VIC, Australia., Segrave RA; BrainPark, Turner Institute for Brain and Mental Health, School of Psychological Sciences and Monash Biomedical Imaging Facility, Monash University, Clayton, VIC, Australia., Hughes S; BrainPark, Turner Institute for Brain and Mental Health, School of Psychological Sciences and Monash Biomedical Imaging Facility, Monash University, Clayton, VIC, Australia., Kayayan E; BrainPark, Turner Institute for Brain and Mental Health, School of Psychological Sciences and Monash Biomedical Imaging Facility, Monash University, Clayton, VIC, Australia., Oldham S; Developmental Imaging, Murdoch Children's Research Institute, Melbourne, VIC, Australia., Syeda W; Melbourne Brain Centre Imaging Unit, Department of Radiology, The University of Melbourne, Parkville, VIC, Australia., Coxon JP; Movement and Exercise Neuroscience Laboratory, School of Psychological Sciences and Monash Biomedical Imaging Facility, Monash University, Clayton, VIC, Australia., Caeyenberghs K; Cognitive Neuroscience Unit, School of Psychology, Deakin University, Burwood, VIC, Australia., Domínguez D JF; Cognitive Neuroscience Unit, School of Psychology, Deakin University, Burwood, VIC, Australia., Solowij N; School of Psychology, University of Wollongong, Wollongong, NSW, Australia., Lubman DI; Turning Point, Eastern Health, Melbourne, VIC, Australia.; Monash Addiction Research Centre, Eastern Health Clinical School, Monash University, Clayton, VIC, Australia., Suo C; BrainPark, Turner Institute for Brain and Mental Health, School of Psychological Sciences and Monash Biomedical Imaging Facility, Monash University, Clayton, VIC, Australia. chao.suo@monash.edu.; Neuroscience of Addiction and Mental Health Program, Healthy Brain and Mind Research Centre, School of Behavioral and Health Sciences, Faculty of Health Sciences, Australian Catholic University, Fitzroy, VIC, Australia. chao.suo@monash.edu.; QIMR Berghofer Medical Research Institute, Herston, QLD, Australia. chao.suo@monash.edu., Yücel M; BrainPark, Turner Institute for Brain and Mental Health, School of Psychological Sciences and Monash Biomedical Imaging Facility, Monash University, Clayton, VIC, Australia. murat.yucel@qimrb.edu.au.; QIMR Berghofer Medical Research Institute, Herston, QLD, Australia. murat.yucel@qimrb.edu.au.
Jazyk: angličtina
Zdroj: Translational psychiatry [Transl Psychiatry] 2024 Oct 11; Vol. 14 (1), pp. 429. Date of Electronic Publication: 2024 Oct 11.
DOI: 10.1038/s41398-024-03150-0
Abstrakt: Cannabis use disorder (CUD) is associated with adverse mental health effects, as well as social and cognitive impairment. Given prevalence rates of CUD are increasing, there is considerable efforts, and need, to identify prognostic markers which may aid in minimising any harm associated with this condition. Previous neuroimaging studies have revealed changes in white matter (WM) organization in people with CUD, though, the findings are mixed. In this study, we applied MRI-based analysis techniques that offer complimentary mechanistic insights, i.e., a connectome approach and fixel-based analysis (FBA) to investigate properties of individual WM fibre populations and their microstructure across the entire brain, providing a highly sensitive approach to detect subtle changes and overcome limitations of previous diffusion models. We compared 56 individuals with CUD (median age 25 years) to a sample of 38 healthy individuals (median age 31.5 years). Compared to controls, those with CUD had significantly increased structural connectivity strength (FDR corrected) across 9 edges between the right parietal cortex and several cortical and subcortical regions, including left orbitofrontal, left temporal pole, and left hippocampus and putamen. Utilizing FBA, WM density was significantly higher in those with CUD (FWE-corrected) across the splenium of the corpus callosum, and lower in the bilateral cingulum and right cerebellum. We observed significant correlation between cannabis use over the past month and connectivity strength of the frontoparietal edge, and between age of regular use and WM density of the bilateral cingulum and right cerebellum. Our findings enhance the understanding of WM architecture alterations associated with CUD.
(© 2024. The Author(s).)
Databáze: MEDLINE
Externí odkaz: