Emerging roles of antimicrobial peptides in innate immunity, neuronal function, and neurodegeneration.

Autor: Lee S; Frontotemporal Dementia Research Center, RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Silverman N; Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA. Electronic address: neal.silverman@umassmed.edu., Gao FB; Frontotemporal Dementia Research Center, RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA. Electronic address: fen-biao.gao@umassmed.edu.
Jazyk: angličtina
Zdroj: Trends in neurosciences [Trends Neurosci] 2024 Nov; Vol. 47 (11), pp. 949-961. Date of Electronic Publication: 2024 Oct 09.
DOI: 10.1016/j.tins.2024.09.001
Abstrakt: Antimicrobial peptides (AMPs), a collection of small proteins with important roles in classical innate immunity, have been extensively studied in multiple organisms, particularly in Drosophila melanogaster. Advances in CRISPR/Cas9 genome editing have allowed individual AMP functions to be dissected, revealing specific and selective roles in host defense. Recent findings have also revealed many unexpected contributions of endogenous AMPs to neuronal functions and neurodegenerative diseases, and have shed light on the intersections between innate immunity and neurobiology. We explore the intricate relationships between AMPs and sleep regulation, memory formation, as well as traumatic brain injury and several neurodegenerative diseases such as Alzheimer's disease (AD), frontotemporal dementia (FTD), and Parkinson's disease (PD). Understanding the diverse functions of AMPs opens new avenues for neuroinflammation and neurodegenerative disease research and potential therapeutic development.
Competing Interests: Declaration of interests F-B.G. received funding and completed a research project with Stealth BioTherapeutics. F-B.G. serves on the research advisory board of the Muscular Dystrophy Association and the Medical Advisory Council of the Association for Frontotemporal Degeneration without any financial compensation. F-B.G. holds two patents (US10905707 and US63414050) describing compounds that may be used to treat one of the diseases discussed in this article. S.L. and N.S. declare no competing interests.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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