Neurocutaneous disorders identified in the neonatal period and infancy: Hypomelanosis of Ito.

Autor: Zakhary G; Division of Child Neurology, Nationwide Children's Hospital, Columbus, OH, USA. Electronic address: George.Zakhary@nationwidechildrens.org., Ream M; Division of Child Neurology, Nationwide Children's Hospital, Columbus, OH, USA; Department of Pediatrics, The Ohio State University, Columbus, OH, USA. Electronic address: Margie.Ream@nationwidechildrens.org.
Jazyk: angličtina
Zdroj: Seminars in pediatric neurology [Semin Pediatr Neurol] 2024 Oct; Vol. 51, pp. 101154. Date of Electronic Publication: 2024 Sep 12.
DOI: 10.1016/j.spen.2024.101154
Abstrakt: Hypomelanosis of Ito is a rare neurocutaneous disorder named after the Japanese dermatologist Minoru Ito who in 1952 described the condition. Characteristically, the hypopigmented lesions in this condition follow Blaschko lines. Extracutaneous manifestations of the disease include neurological, musculoskeletal, cardiac, endocrine, and renal signs and symptoms. The most common neurological manifestation is cognitive impairment. Seizures, developmental delay, and abnormal tone can also be present. In this review we discuss the condition's clinical presentations, its diagnostic criteria, and consensus recommendations.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier Inc.)
Databáze: MEDLINE
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