Pharmacodynamic target attainment at infection site during treatment of post-neurosurgical ventriculitis caused by carbapenem-resistant klebsiella pneumoniae with ceftazidime-avibactam-based regimens: a case report.

Autor: Chen Y; Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China; Key Laboratory of Clinical Pharmacology of Antibiotics, Shanghai, China; National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China; School of Pharmacy, Fudan University, Shanghai, China., Li W; Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China; Key Laboratory of Clinical Pharmacology of Antibiotics, Shanghai, China; National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China., Liu X; Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China; Key Laboratory of Clinical Pharmacology of Antibiotics, Shanghai, China; National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China., Chen Y; Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China; Key Laboratory of Clinical Pharmacology of Antibiotics, Shanghai, China; National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China., Zhang J; Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China; Key Laboratory of Clinical Pharmacology of Antibiotics, Shanghai, China; National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China; Clinical Pharmacology Research Center, Huashan Hospital, Fudan University, Shanghai, China., Li N; Clinical Pharmacology Research Center, Huashan Hospital, Fudan University, Shanghai, China. Electronic address: linanyang1213@163.com., Yang L; Department of Neurosurgery & Neurocritical Care, Huashan Hospital, Fudan University, Shanghai, China. Electronic address: leiyangdr@163.com.
Jazyk: angličtina
Zdroj: International journal of antimicrobial agents [Int J Antimicrob Agents] 2024 Dec; Vol. 64 (6), pp. 107356. Date of Electronic Publication: 2024 Oct 09.
DOI: 10.1016/j.ijantimicag.2024.107356
Abstrakt: A patient developed a post-neurosurgical ventriculitis with carbapenem-resistant Klebsiella pneumoniae and mold, initially treated with ceftazidime/avibactam and voriconazole. A Klebsiella pneumoniae carbapenemase mutation led to therapy adjustment to ceftazidime/avibactam and polymyxin B, achieving cure. Pharmacokinetic/pharmacodynamic analysis highlights effective ceftazidime/avibactam brain penetration and bacterial clearance efficacy.
Competing Interests: Declarations Funding: This study was supported by a Pfizer Independent Medical Grant (Pfizer Tracking Number 55877037 and 2021QD004). Competing Interests: All authors report no potential conflicts. Ethical Approval: Not required Sequence Information: Not applicable Author contributions: Lei Yang and Nanyang Li cared for the patient and collected the data. Yinru Chen and Wanzhen Li wrote the manuscript, did the statistical analysis and prepared the graphs. Wanzhen Li measured the concentration of CAZ and AVI. Xiaofen Liu and Yan Chen measured the concentration of PMB. Jing Zhang reviewed the patient's medical history and the manuscript. Written consent for publication was obtained from the patient.
(Copyright © 2024. Published by Elsevier Ltd.)
Databáze: MEDLINE
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