Role of the Crosstalk B:Neoplastic T Follicular Helper Cells in the Pathobiology of Nodal T Follicular Helper Cell Lymphomas.

Autor:	Sainz TP; Department of Hematopathology, MD Anderson Cancer Center, The University of Texas, Houston, Texas., Sahu V; Department of Hematopathology, MD Anderson Cancer Center, The University of Texas, Houston, Texas., Gomez JA; Department of Leukemia, MD Anderson Cancer Center, The University of Texas, Houston, Texas., Dcunha NJ; Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas., Basi AV; Department of Leukemia, MD Anderson Cancer Center, The University of Texas, Houston, Texas., Kettlun C; Department of Hematopathology, MD Anderson Cancer Center, The University of Texas, Houston, Texas., Sarami I; Department of Hematopathology, MD Anderson Cancer Center, The University of Texas, Houston, Texas., Burks JK; Department of Leukemia, MD Anderson Cancer Center, The University of Texas, Houston, Texas., Sampath D; Hematopoietic Biology and Malignancy, MD Anderson Cancer Center, The University of Texas, Houston, Texas., Vega F; Department of Hematopathology, MD Anderson Cancer Center, The University of Texas, Houston, Texas. Electronic address: fvega@mdanderson.org.
Jazyk:	angličtina
Zdroj:	Laboratory investigation; a journal of technical methods and pathology [Lab Invest] 2024 Nov; Vol. 104 (11), pp. 102147. Date of Electronic Publication: 2024 Oct 09.
DOI:	10.1016/j.labinv.2024.102147
Abstrakt:	Angioimmunoblastic T-cell lymphoma (AITL), the most common form of peripheral T-cell lymphoma, originates from follicular helper T (Tfh) cells and is notably resistant to current treatments. The disease progression and maintenance, at least in early stages, are driven by a complex interplay between neoplastic Tfh and clusters of B-cells within the tumor microenvironment, mirroring the functional crosstalk observed inside germinal centers. This interaction is further complicated by recurrent mutations, such as TET2 and DNMT3A, which are present in both Tfh cells and B-cells. These findings suggest that the symbiotic relationship between these 2 cell types could represent a therapeutic vulnerability. This review examines the key components and signaling mechanisms involved in the synapses between B-cells and Tfh cells, emphasizing their significant role in the pathobiology of AITL and potential as therapeutic targets. (Copyright © 2024 United States & Canadian Academy of Pathology. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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